Schizophrenia and bipolar disorder are among the most chronic and debilitating of psychiatric syndromes and, with a lifetime prevalence of about 1% each, represent major public health concerns. While traditionally viewed as distinct from each other, recent work has revealed substantial familial co-aggregation and overlap in the genomic regions showing linkage and association with these two disorders. Elucidating the specific genetic and neural mechanisms influencing susceptibility to and expression of these illnesses, and explaining the nature of the overlap between them, is critical to understanding the necessary and sufficient conditions for overt psychosis and to the development of more effective treatment and prevention strategies. To gain traction on these issues, we propose to investigate the inheritance of neural dysfunctions in schizophrenia and bipolar disorder in population-based samples of monozygotic (MZ) and dizygotic (DZ) twin pairs concordant and discordant for these two conditions along with healthy control pairs recruited from the Swedish Twin Registry. Participants will be evaluated with structured clinical interviews, magnetic resonance imaging (MRI) scans of the brain, and a comprehensive neuropsychological test battery, and we will obtain blood samples for DNA extraction and genotyping. This information will be used: 1) to elucidate neural traits that vary in dose-dependent fashion with genetic liability to schizophrenia and bipolar disorder among unaffected MZ and DZ co-twins and control twins and to clarify the extent of overlap in these features between the two syndromes;2) to investigate genomic regions previously linked to schizophrenia and/or bipolar disorder for association with these neural endophenotypes and overt psychosis;and 3) to isolate non-genetic neural changes that are unique to or more severe in individuals who manifest overt schizophrenia or bipolar disorder compared with their unaffected MZ co-twins and determine the contributions of obstetric complications and other non-genetic influences to these neural changes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH052857-14
Application #
7813779
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Meinecke, Douglas L
Project Start
1995-09-30
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2012-04-30
Support Year
14
Fiscal Year
2010
Total Cost
$535,869
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Allswede, Dana M; Zheutlin, Amanda B; Chung, Yoonho et al. (2018) Complement Gene Expression Correlates with Superior Frontal Cortical Thickness in Humans. Neuropsychopharmacology 43:525-533
Johansson, Viktoria; Hultman, Christina M; Kizling, Isabelle et al. (2018) The schizophrenia and bipolar twin study in Sweden (STAR). Schizophr Res :
Fortgang, Rebecca G; Hultman, Christina M; Cannon, Tyrone D (2016) Coping Styles in Twins Discordant for Schizophrenia, Bipolar Disorder, and Depression. Clin Psychol Sci 4:216-228
Fortgang, R G; Hultman, C M; van Erp, T G M et al. (2016) Multidimensional assessment of impulsivity in schizophrenia, bipolar disorder, and major depressive disorder: testing for shared endophenotypes. Psychol Med 46:1497-507
Zheutlin, Amanda B; Viehman, Rachael W; Fortgang, Rebecca et al. (2016) Cognitive endophenotypes inform genome-wide expression profiling in schizophrenia. Neuropsychology 30:40-52
Hannon, Eilis; Dempster, Emma; Viana, Joana et al. (2016) An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation. Genome Biol 17:176
Higier, Rachel G; Jimenez, Amy M; Hultman, Christina M et al. (2014) Enhanced neurocognitive functioning and positive temperament in twins discordant for bipolar disorder. Am J Psychiatry 171:1191-8
Bloom, Rachael J; Kähler, Anna K; Collins, Ann L et al. (2013) Comprehensive analysis of copy number variation in monozygotic twins discordant for bipolar disorder or schizophrenia. Schizophr Res 146:289-90
Johansson, Viktoria; Nybom, Rolf; Wetterberg, Lennart et al. (2012) Microscopic particles in two fractions of fresh cerebrospinal fluid in twins with schizophrenia or bipolar disorder and in healthy controls. PLoS One 7:e45994
Loewy, Rachel L; Therman, Sebastian; Manninen, Marko et al. (2012) Prodromal psychosis screening in adolescent psychiatry clinics. Early Interv Psychiatry 6:69-75

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