This competing renewal application is a revision of what was previously a Collaborative R0l three site prospective study of middle-aged women's mental health that is an ancillary study of the Study of Women' Health Across the Nation (SWAN). Due to difficulty with retention and feasibility issues at the other 2 sites they will be unable to continue the study. We are proposing to continue the study in Pittsburgh only. Our current sample consists of 412 African American and Caucasian women, aged 42-52 at the start of the study in 1996, who are beginning or will soon begin the menopausal transition. Women are interviewed annually with the Structured Clinical Interview (SCID) for DSM-IV Axis I Disorders.
Our specific aims are: 1) to assess whether women will be more likely to develop a new (recurrent) syndromal or subsyndromal depression during the perimenopausal transition than before or after, 2) to determine if a history of major depression (MOD) is risk factor for the following during the transition: (a) syndromal or subsyndromal depression, (b) increased levels of perceived stress, somatic and psychological symptoms, or (c) decreased quality of life or functioning and 3) to compare rates of new (recurrent) syndromal or subsyndromal depression across the transition for African American and Caucasian women. The longitudinal nature of the SWAN biological and psychosocial data (e.g., medical morbidity, stressful events, lifestyle behaviors) will allow us to evaluate these as antecedents, correlates, and consequences of depression during the course of the study. By continuing to collect systematically psychiatric data in our cohort in conjunction with the continued collection of Core SWAN data, we have a unique opportunity to expand knowledge of women's mental health in midlife and beyond.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH059689-04
Application #
6528550
Study Section
Special Emphasis Panel (ZRG1-SNEM-2 (01))
Program Officer
Otey, Emeline M
Project Start
1999-08-15
Project End
2006-08-31
Budget Start
2002-09-01
Budget End
2003-08-31
Support Year
4
Fiscal Year
2002
Total Cost
$260,991
Indirect Cost
Name
University of Pittsburgh
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Everson-Rose, Susan A; Clark, Cari J; Wang, Qi et al. (2018) Depressive symptoms and adipokines in women: Study of women's health across the nation. Psychoneuroendocrinology 97:20-27
Colvin, Alicia; Richardson, Gale A; Cyranowski, Jill M et al. (2017) The role of family history of depression and the menopausal transition in the development of major depression in midlife women: Study of women's health across the nation mental health study (SWAN MHS). Depress Anxiety 34:826-835
Bromberger, Joyce T; Kravitz, Howard M; Youk, Ada et al. (2016) Patterns of depressive disorders across 13 years and their determinants among midlife women: SWAN mental health study. J Affect Disord 206:31-40
Bromberger, J T; Schott, L; Kravitz, H M et al. (2015) Risk factors for major depression during midlife among a community sample of women with and without prior major depression: are they the same or different? Psychol Med 45:1653-64
Matthews, Karen A; Chang, Yue-Fang; Thurston, Rebecca C et al. (2014) Child abuse is related to inflammation in mid-life women: role of obesity. Brain Behav Immun 36:29-34
Kravitz, H M; Schott, L L; Joffe, H et al. (2014) Do anxiety symptoms predict major depressive disorder in midlife women? The Study of Women's Health Across the Nation (SWAN) Mental Health Study (MHS). Psychol Med 44:2593-602
Colvin, Alicia; Richardson, Gale A; Cyranowski, Jill M et al. (2014) Does family history of depression predict major depression in midlife women? Study of Women's Health Across the Nation Mental Health Study (SWAN MHS). Arch Womens Ment Health 17:269-78
Bromberger, Joyce T; Kravitz, Howard M; Chang, Yuefang et al. (2013) Does risk for anxiety increase during the menopausal transition? Study of women's health across the nation. Menopause 20:488-95
Midei, Aimee J; Matthews, Karen A; Chang, Yue-Fang et al. (2013) Childhood physical abuse is associated with incident metabolic syndrome in mid-life women. Health Psychol 32:121-7
Bromberger, Joyce T; Schott, Laura L; Matthews, Karen A et al. (2012) Association of past and recent major depression and menstrual characteristics in midlife: Study of Women's Health Across the Nation. Menopause 19:959-66

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