The purpose of this grant is to understand how temporal information processing affects learning. Temporal factors affect the speed of learning and how that learning is expressed. The experiments proposed here analyze the specific ways in which the temporal pattern of events affects associative learning. The studies analyze how events are integrated or segregated into different memory representations and how these representations are used to determine response strength, choice and inference. The studies will lead to a better understanding of learning and, more specifically, of how one learns to anticipate predictable events. There are deficits in timing and anticipation in many behavior disorders. Depression, schizophrenia, and attention-deficit-hyperactivity disorder are all associated with distortions in time perception and changes in the capacity to anticipate predictable events. Drug taking and other habitual high risk behaviors are associated with a diminished capacity to anticipate long-term consequences. An understanding of the mechanisms of anticipatory learning will lead to more effective behavioral and biological treatments.
| Bailey, Matthew R; Goldman, Olivia; Bello, EstefanÃa P et al. (2018) An Interaction between Serotonin Receptor Signaling and Dopamine Enhances Goal-Directed Vigor and Persistence in Mice. J Neurosci 38:2149-2162 |
| Cassidy, Clifford M; Balsam, Peter D; Weinstein, Jodi J et al. (2018) A Perceptual Inference Mechanism for Hallucinations Linked to Striatal Dopamine. Curr Biol 28:503-514.e4 |
| Demireva, Elena Y; Suri, Deepika; Morelli, Emanuela et al. (2018) 5-HT2C receptor blockade reverses SSRI-associated basal ganglia dysfunction and potentiates therapeutic efficacy. Mol Psychiatry : |
| Nautiyal, Katherine M; Wall, Melanie M; Wang, Shuai et al. (2017) Genetic and Modeling Approaches Reveal Distinct Components of Impulsive Behavior. Neuropsychopharmacology 42:1182-1191 |
| Drew, Michael R; Walsh, Carolyn; Balsam, Peter D (2017) Rescaling of temporal expectations during extinction. J Exp Psychol Anim Learn Cogn 43:1-14 |
| Matamales, Miriam; Skrbis, Zala; Bailey, Matthew R et al. (2017) A corticostriatal deficit promotes temporal distortion of automatic action in ageing. Elife 6: |
| Tarullo, Amanda R; Isler, Joseph R; Condon, Carmen et al. (2016) Neonatal eyelid conditioning during sleep. Dev Psychobiol 58:875-882 |
| Kirkpatrick, Kimberly; Balsam, Peter D (2016) Associative learning and timing. Curr Opin Behav Sci 8:181-185 |
| Carvalho Poyraz, Fernanda; Holzner, Eva; Bailey, Matthew R et al. (2016) Decreasing Striatopallidal Pathway Function Enhances Motivation by Energizing the Initiation of Goal-Directed Action. J Neurosci 36:5988-6001 |
| Crossley, Matthew J; Horvitz, Jon C; Balsam, Peter D et al. (2016) Expanding the role of striatal cholinergic interneurons and the midbrain dopamine system in appetitive instrumental conditioning. J Neurophysiol 115:240-54 |
Showing the most recent 10 out of 54 publications
