The GAIN program will complete a 600,000 tag SNP genome-wide association scan of 956 parent-child trios from the PI's International Multi-site ADHD Genetics (IMAGE) project. In this proposal we are requesting funds for the analysis of these data. The overarching aim of this proposal is to complete a comprehensive analysis of the whole genome scan (WGAS) data in a manner that will provide insights into the genetic etiology of ADHD and associated features. We will do this by completing the following: 1) assessing the association of GAIN SNP's with the ADHD diagnostic phenotype, 2) Imputing genotypes for siblings in the GAIN trio families, 3) Assessing the association of GAIN SNP's with the quantitative ADHD phenotypes, 4) conducting copy number analyses, 5) assessing parent of origin effects; 6) assessing season of birth effects and 7) testing for epistasis. The IMAGE project is now in the process of creating an international resource for molecular genetic studies of ADHD by sharing the study's clinical and genetic data with the scientific community through the NIMH genetic data repositories. All clinical and DNA data from our samples has been sent to the NIMH DNA and clinical data repositories for release to the scientific community. All genotype data generated by the GAIN whole genome association scan will be made available to the scientific community by GAIN as soon as the genotypes are completed. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
1R01MH081803-01
Application #
7343411
Study Section
Special Emphasis Panel (ZMH1-ERB-C (02))
Program Officer
Lehner, Thomas
Project Start
2007-09-27
Project End
2009-09-26
Budget Start
2007-09-27
Budget End
2009-09-26
Support Year
1
Fiscal Year
2007
Total Cost
$157,000
Indirect Cost
Name
Upstate Medical University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
058889106
City
Syracuse
State
NY
Country
United States
Zip Code
13210
van Ewijk, Hanneke; Bralten, Janita; van Duin, Esther D A et al. (2017) Female-specific association of NOS1 genotype with white matter microstructure in ADHD patients and controls. J Child Psychol Psychiatry 58:958-966
Richards, Jennifer S; Arias Vásquez, Alejandro; van Rooij, Daan et al. (2017) Testing differential susceptibility: Plasticity genes, the social environment, and their interplay in adolescent response inhibition. World J Biol Psychiatry 18:308-321
Naaijen, J; Bralten, J; Poelmans, G et al. (2017) Glutamatergic and GABAergic gene sets in attention-deficit/hyperactivity disorder: association to overlapping traits in ADHD and autism. Transl Psychiatry 7:e999
Hoogman, Martine; Bralten, Janita; Hibar, Derrek P et al. (2017) Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry 4:310-319
Thapar, A; Martin, J; Mick, E et al. (2016) Psychiatric gene discoveries shape evidence on ADHD's biology. Mol Psychiatry 21:1202-7
Richards, Jennifer S; Arias Vásquez, Alejandro; Franke, Barbara et al. (2016) Developmentally Sensitive Interaction Effects of Genes and the Social Environment on Total and Subcortical Brain Volumes. PLoS One 11:e0155755
Zayats, T; Jacobsen, K K; Kleppe, R et al. (2016) Exome chip analyses in adult attention deficit hyperactivity disorder. Transl Psychiatry 6:e923
Richards, J S; Arias Vásquez, A; von Rhein, D et al. (2016) Adolescent behavioral and neural reward sensitivity: a test of the differential susceptibility theory. Transl Psychiatry 6:e771
Onnink, A Marten H; Franke, Barbara; van Hulzen, Kimm et al. (2016) Enlarged striatal volume in adults with ADHD carrying the 9-6 haplotype of the dopamine transporter gene DAT1. J Neural Transm (Vienna) 123:905-15
Zuo, Lingjun; Tan, Yunlong; Li, Chiang-Shan R et al. (2016) Associations of rare nicotinic cholinergic receptor gene variants to nicotine and alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 171:1057-1071

Showing the most recent 10 out of 61 publications