Abstract

The purpose of this research is to contribute to our understanding of the neuronal machinery responsible for learning and response selection in complex, integrated behavioral repertoires. These related problems are to be studied in a relatively simple system, the crayfish escape response repertoire, which consists of a small set of escape responses all of which are subject to habituation and probably also to other forms of plastic modification. Specific behavioral and electrophysiological research is proposed on (1) cellular mechanisms of associative learning, (2) effects of neuron activity on synapse formation and maintenance, and (3) the neural circuitry that is responsible for generating escape behavior and for integrating it with the overall behavior of the animal.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS008108-18
Application #
3393710
Study Section
Biopsychology Study Section (BPO)
Project Start
1978-07-01
Project End
1986-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
18
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Schools of Arts and Sciences
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Lee, Sun Hee Cho; Taylor, Karen; Krasne, Franklin B (2008) Reciprocal stimulation of decay between serotonergic facilitation and depression of synaptic transmission. J Neurophysiol 100:1113-26
Vu, E T; Lee, S C; Krasne, F B (1993) The mechanism of tonic inhibition of crayfish escape behavior: distal inhibition and its functional significance. J Neurosci 13:4379-93
Lee, S C; Krasne, F B (1993) Ultrastructure of the circuit providing input to the crayfish lateral giant neurons. J Comp Neurol 327:271-88
Vu, E T; Krasne, F B (1993) Crayfish tonic inhibition: prolonged modulation of behavioral excitability by classical GABAergic inhibition. J Neurosci 13:4394-402
Miller, M W; Vu, E T; Krasne, F B (1992) Cholinergic transmission at the first synapse of the circuit mediating the crayfish lateral giant escape reaction. J Neurophysiol 68:2174-84
Krasne, F B; Lee, S C (1988) Response-dedicated trigger neurons as control points for behavioral actions: selective inhibition of lateral giant command neurons during feeding in crayfish. J Neurosci 8:3703-12
Krasne, F B (1987) Silencing normal input permits regenerating foreign afferents to innervate an identified crayfish sensory interneuron. J Neurobiol 18:61-73
Miller, M W; Lee, S C; Krasne, F B (1987) Cooperativity-dependent long-lasting potentiation in the crayfish lateral giant escape reaction circuit. J Neurosci 7:1081-92
Glanzman, D L; Krasne, F B (1986) 5,7-Dihydroxytryptamine lesions of crayfish serotonin-containing neurons: effect on the lateral giant escape reaction. J Neurosci 6:1560-9
Krasne, F B; Glanzman, D L (1986) Sensitization of the crayfish lateral giant escape reaction. J Neurosci 6:1013-20

Showing the most recent 10 out of 11 publications