Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS011615-23
Application #
2262336
Study Section
Neurology C Study Section (NEUC)
Project Start
1978-09-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
23
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Jurevics, Helga; Hostettler, Janell; Sammond, Deanne W et al. (2003) Normal metabolism but different physical properties of myelin from mice deficient in proteolipid protein. J Neurosci Res 71:826-34
Jurevics, Helga; Largent, Carrie; Hostettler, Janell et al. (2002) Alterations in metabolism and gene expression in brain regions during cuprizone-induced demyelination and remyelination. J Neurochem 82:126-36
Jurevics, H; Hostettler, J; Muse, E D et al. (2001) Cerebroside synthesis as a measure of the rate of remyelination following cuprizone-induced demyelination in brain. J Neurochem 77:1067-76
Muse, E D; Jurevics, H; Toews, A D et al. (2001) Parameters related to lipid metabolism as markers of myelination in mouse brain. J Neurochem 76:77-86
Matsushima, G K; Morell, P (2001) The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system. Brain Pathol 11:107-16
Mason, J L; Langaman, C; Morell, P et al. (2001) Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre. Neuropathol Appl Neurobiol 27:50-8
Mason, J L; Jones, J J; Taniike, M et al. (2000) Mature oligodendrocyte apoptosis precedes IGF-1 production and oligodendrocyte progenitor accumulation and differentiation during demyelination/remyelination. J Neurosci Res 61:251-62
Jurevics, H; Hostettler, J; Barrett, C et al. (2000) Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase. J Lipid Res 41:1048-54
Goodrum, J F; Fowler, K A; Hostettler, J D et al. (2000) Peripheral nerve regeneration and cholesterol reutilization are normal in the low-density lipoprotein receptor knockout mouse. J Neurosci Res 59:581-6
Jurevics, H; Bouldin, T W; Toews, A D et al. (1998) Regenerating sciatic nerve does not utilize circulating cholesterol. Neurochem Res 23:401-6

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