Abstract

The research which we now propose to carry out covers a synthetic area of natural products chemistry. The proposal includes: (1) total synthesis of ansamycin antibotics, rifamycin (2) total synthesis of polyether antibiotics, narasin, (3) total synthesis of optically active gephyrotoxin, (4) total synthesis of gonyautoxins, (5) total synthesis of histrionicotoxin, and (6) total synthesis of palytoxin. We belive these proposed studies of natural products will very effectively extend the scope of synthetic organic chemistry.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS012108-11
Application #
3394713
Study Section
(SSS)
Project Start
1978-06-01
Project End
1988-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code

  Publications

Jensen, Erik A; Allen, Benjamin D; Kishi, Yoshito et al. (2008) Conformational analysis of a covalently cross-linked Watson-Crick base pair model. Bioorg Med Chem Lett 18:5884-7
Meppen, Malte; Wang, Yonghui; Cheon, Hwan-Sung et al. (2007) Synthetic 6-O-methylglucose-containing polysaccharides (sMGPs): design and synthesis. J Org Chem 72:1941-50
Hsu, Margaret C; Lee, Jinhwa; Kishi, Yoshito (2007) Synthetic 3-O-methylmannose-containing polysaccharides (sMMPs): design and synthesis. J Org Chem 72:1931-40
Wang, Yonghui; Ma, Jianguo; Cheon, Hwan-Sung et al. (2007) Aggregation behavior of tetraenoic fatty acids in aqueous solution. Angew Chem Int Ed Engl 46:1333-6
Hao, Junliang; Matsuura, Fumiyoshi; Kishi, Yoshito et al. (2006) Stereochemistry of pteriatoxins A, B, and C. J Am Chem Soc 128:7742-3
Matsuura, Fumiyoshi; Peters, Rene; Anada, Masahiro et al. (2006) Unified total synthesis of pteriatoxins and their diastereomers. J Am Chem Soc 128:7463-5
Matsuura, Fumiyoshi; Hao, Junliang; Reents, Reinhard et al. (2006) Total synthesis and stereochemistry of pinnatoxins B and C. Org Lett 8:3327-30
Ghosh, Indranath; Zeng, Hongbo; Kishi, Yoshito (2004) Application of chiral lanthanide shift reagents for assignment of absolute configuration of alcohols. Org Lett 6:4715-8
Adams, Christopher M; Ghosh, Indranath; Kishi, Yoshito (2004) Validation of lanthanide chiral shift reagents for determination of absolute configuration: total synthesis of glisoprenin A. Org Lett 6:4723-6
Ghosh, Indranath; Kishi, Yoshito; Tomoda, Hiroshi et al. (2004) Use of a chiral praseodymium shift reagent in predicting the complete stereostructure of glisoprenin A. Org Lett 6:4719-22

Showing the most recent 10 out of 21 publications