Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS012389-19S1
Application #
3394834
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1978-06-01
Project End
1999-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
19
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Aron, Zachary D; Ito, Tatsuya; May, Tricia L et al. (2013) Enantioselective synthesis of angularly substituted 1-azabicylic rings: coupled dynamic kinetic epimerization and chirality transfer. J Org Chem 78:9929-48
Canham, Stephen M; France, David J; Overman, Larry E (2013) Total synthesis of (+)-sieboldine a: evolution of a pinacol-terminated cyclization strategy. J Org Chem 78:9-34
Schnermann, Martin J; Untiedt, Nicholas L; Jimenez-Oses, Gonzalo et al. (2012) Forming tertiary organolithiums and organocuprates from nitrile precursors and their bimolecular reactions with carbon electrophiles to form quaternary carbon stereocenters. Angew Chem Int Ed Engl 51:9581-6
Schnermann, Martin J; Overman, Larry E (2012) A concise synthesis of (-)-aplyviolene facilitated by a strategic tertiary radical conjugate addition. Angew Chem Int Ed Engl 51:9576-80
Canham, Stephen M; Overman, Larry E; Tanis, Paul S (2011) Identification of an Unexpected 2-Oxonia[3,3]sigmatropic Rearrangement/Aldol Pathway in the Formation of Oxacyclic Rings. Total Synthesis of (+)-Aspergillin PZ. Tetrahedron 67:9837-9843
Martin, Connor L; Nakamura, Seiichi; Otte, Ralf et al. (2011) Total synthesis of (+)-condylocarpine, (+)-isocondylocarpine, and (+)-tubotaiwine. Org Lett 13:138-41
Schnermann, Martin J; Overman, Larry E (2011) Enantioselective total synthesis of aplyviolene. J Am Chem Soc 133:16425-7
Schnermann, Martin J; Beaudry, Christopher M; Genung, Nathan E et al. (2011) Divergent synthesis and chemical reactivity of bicyclic lactone fragments of complex rearranged spongian diterpenes. J Am Chem Soc 133:17494-503
Altman, Ryan A; Nilsson, Bradley L; Overman, Larry E et al. (2010) Total synthesis of (+)-nankakurines A and B and (±)-5-epi-nankakurine A. J Org Chem 75:7519-34
Overman, Larry E; Tanis, Paul S (2010) Origin of stereocontrol in the construction of the 12-oxatricyclo[6.3.1.0(2,7)]dodecane ring system by Prins-pinacol reactions. J Org Chem 75:455-63

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