Several categories of experiments on monkeys are planned with the broad goal of better understanding the organization, development, and injury related plasticity of sensory and motor systems in humans. (1) Normal organization and connection patterns will be investigated at cortical, brainstem, and spinal cord levels with the use of microelectrode mapping methods, single unit recordings, and a range of anatomical tracers. This information is basic for understandings of how complex sensory systems of higher primates process information and produce motor patterns. The results also serve as a comparison and control for investigation of injury induced plasticity in adult and developing systems. (2) Limited studies on the normal development of cortical sensory representations and connections will use the same methods, and will be important in both understanding normal development and how injury to developing systems can alter development. (3) A major part of the research program will be directed toward understanding how adult and developing somatosensory systems reorganize as a result of peripheral nerve injury with and without regeneration. Cortical representations of the hand will be studied for alterations from normal organization with microelectrode mapping methods, and the condition of regenerated and adjacent intact nerves will be evaluated independently with anatomical tracing methods. The results will have major implications for understanding of the consequences of nerve and brain injury in adult and developing humans, and should provide information relevant to repair and treatment strategies. In addition, the results will be important in constructing and revising theories of how the nervous system develops and self-organizes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS016446-12
Application #
3396892
Study Section
Neurology A Study Section (NEUA)
Project Start
1980-07-01
Project End
1994-11-30
Budget Start
1991-12-01
Budget End
1992-11-30
Support Year
12
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
Schools of Arts and Sciences
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Padberg, Jeffrey; Cooke, Dylan F; Cerkevich, Christina M et al. (2018) Cortical connections of area 2 and posterior parietal area 5 in macaque monkeys. J Comp Neurol :
Liao, Chia-Chi; Reed, Jamie L; Qi, Hui-Xin et al. (2018) Second-order spinal cord pathway contributes to cortical responses after long recoveries from dorsal column injury in squirrel monkeys. Proc Natl Acad Sci U S A 115:4258-4263
Cerkevich, Christina M; Kaas, Jon H (2018) Corticocortical projections to area 1 in squirrel monkeys (Saimiri sciureus). Eur J Neurosci :
Kaas, Jon H; Stepniewska, Iwona (2016) Evolution of posterior parietal cortex and parietal-frontal networks for specific actions in primates. J Comp Neurol 524:595-608
Qi, Hui-Xin; Wang, Feng; Liao, Chia-Chi et al. (2016) Spatiotemporal trajectories of reactivation of somatosensory cortex by direct and secondary pathways after dorsal column lesions in squirrel monkeys. Neuroimage 142:431-453
Liao, Chia-Chi; Reed, Jamie L; Kaas, Jon H et al. (2016) Intracortical connections are altered after long-standing deprivation of dorsal column inputs in the hand region of area 3b in squirrel monkeys. J Comp Neurol 524:1494-526
Sawyer, Eva K; Turner, Emily C; Kaas, Jon H (2016) Somatosensory brainstem, thalamus, and cortex of the California sea lion (Zalophus californianus). J Comp Neurol 524:1957-75
Qi, Hui-Xin; Reed, Jamie L; Franca, Joao G et al. (2016) Chronic recordings reveal tactile stimuli can suppress spontaneous activity of neurons in somatosensory cortex of awake and anesthetized primates. J Neurophysiol 115:2105-23
Liao, Chia-Chi; Reed, Jamie L; Qi, Hui-Xin (2016) Anatomical changes in the somatosensory system after large sensory loss predict strategies to promote functional recovery after spinal cord injury. Neural Regen Res 11:575-7
Liao, Chia-Chi; Qi, Hui-Xin; Reed, Jamie L et al. (2016) Congenital foot deformation alters the topographic organization in the primate somatosensory system. Brain Struct Funct 221:383-406

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