Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS018670-12
Application #
2263469
Study Section
Neurology A Study Section (NEUA)
Project Start
1982-07-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Fayuk, Dmitriy; Aitken, Peter G; Somjen, George G et al. (2002) Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices. J Neurophysiol 87:1924-37
Muller, M (2000) Effects of chloride transport inhibition and chloride substitution on neuron function and on hypoxic spreading-depression-like depolarization in rat hippocampal slices. Neuroscience 97:33-45
Borgdorff, A J; Somjen, G G; Wadman, W J (2000) Two mechanisms that raise free intracellular calcium in rat hippocampal neurons during hypoosmotic and low NaCl treatment. J Neurophysiol 83:81-9
Somjen, G G; Muller, M (2000) Potassium-induced enhancement of persistent inward current in hippocampal neurons in isolation and in tissue slices. Brain Res 885:102-10
Somjen, G G (2000) Enhancement of persistent sodium current by internal fluorescence in isolated hippocampal neurons. Brain Res 885:94-101
Bahar, S; Fayuk, D; Somjen, G G et al. (2000) Mitochondrial and intrinsic optical signals imaged during hypoxia and spreading depression in rat hippocampal slices. J Neurophysiol 84:311-24
Kager, H; Wadman, W J; Somjen, G G (2000) Simulated seizures and spreading depression in a neuron model incorporating interstitial space and ion concentrations. J Neurophysiol 84:495-512
Muller, M; Somjen, G G (2000) Na(+) and K(+) concentrations, extra- and intracellular voltages, and the effect of TTX in hypoxic rat hippocampal slices. J Neurophysiol 83:735-45
Muller, M; Somjen, G G (2000) Na(+) dependence and the role of glutamate receptors and Na(+) channels in ion fluxes during hypoxia of rat hippocampal slices. J Neurophysiol 84:1869-80
Balestrino, M; Young, J; Aitken, P (1999) Block of (Na+,K+)ATPase with ouabain induces spreading depression-like depolarization in hippocampal slices. Brain Res 838:37-44

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