Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS019640-11
Application #
3399742
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1983-01-01
Project End
1993-07-31
Budget Start
1992-12-01
Budget End
1993-07-31
Support Year
11
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Type
Schools of Arts and Sciences
DUNS #
City
Storrs-Mansfield
State
CT
Country
United States
Zip Code
06269
Hata, Katsusuke; Maeno-Hikichi, Yuka; Yumoto, Norihiro et al. (2018) Distinct Roles of Different Presynaptic and Postsynaptic NCAM Isoforms in Early Motoneuron-Myotube Interactions Required for Functional Synapse Formation. J Neurosci 38:498-510
Kastanenka, Ksenia V; Landmesser, Lynn T (2013) Optogenetic-mediated increases in in vivo spontaneous activity disrupt pool-specific but not dorsal-ventral motoneuron pathfinding. Proc Natl Acad Sci U S A 110:17528-33
Maeno-Hikichi, Yuka; Polo-Parada, Luis; Kastanenka, Ksenia V et al. (2011) Frequency-dependent modes of synaptic vesicle endocytosis and exocytosis at adult mouse neuromuscular junctions. J Neurosci 31:1093-105
Park, Gyu-Hwan; Maeno-Hikichi, Yuka; Awano, Tomoyuki et al. (2010) Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) gene. J Neurosci 30:12005-19
Kastanenka, Ksenia V; Landmesser, Lynn T (2010) In vivo activation of channelrhodopsin-2 reveals that normal patterns of spontaneous activity are required for motoneuron guidance and maintenance of guidance molecules. J Neurosci 30:10575-85
Wang, Sheng; Polo-Parada, Luis; Landmesser, Lynn T (2009) Characterization of rhythmic Ca2+ transients in early embryonic chick motoneurons: Ca2+ sources and effects of altered activation of transmitter receptors. J Neurosci 29:15232-44
Kariya, Shingo; Park, Gyu-Hwan; Maeno-Hikichi, Yuka et al. (2008) Reduced SMN protein impairs maturation of the neuromuscular junctions in mouse models of spinal muscular atrophy. Hum Mol Genet 17:2552-69
Hanson, M Gartz; Milner, Louise D; Landmesser, Lynn T (2008) Spontaneous rhythmic activity in early chick spinal cord influences distinct motor axon pathfinding decisions. Brain Res Rev 57:77-85
Hata, Katsusuke; Polo-Parada, Luis; Landmesser, Lynn T (2007) Selective targeting of different neural cell adhesion molecule isoforms during motoneuron myotube synapse formation in culture and the switch from an immature to mature form of synaptic vesicle cycling. J Neurosci 27:14481-93
Herlitze, Stefan; Landmesser, Lynn T (2007) New optical tools for controlling neuronal activity. Curr Opin Neurobiol 17:87-94

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