A research program is outlined dealing with hemispheric specialization at the interface of language and cognition. A convergent approach is proposed combining three experimental populations and three broad types of experimental paradigms. The subjects include (i) commissurotomy (split-brain) patients, (ii) hemisphere-damaged patients and, (iii) normal children and adults. The techniques include (i) continuous viewing of complex lateralized visual stimuli, (ii) metabolic, blood flow and magnetic real time indices of cerebral activation, (iii) more traditional paradigms of hemifield tachistoscopy, dichotic listening and dual task interference. Complementary models of hemispheric specialization are developed, motivated by the clinical populations and applied to the normal brain. One set of hemifield decision and facilitation experiments illustrates the """"""""direct access"""""""" model; a second set of dichotic listening experiments illustrates the """"""""callosal relay"""""""" model; and a third set studies types, development and modulation of interhemispheric interaction. A fourth set of experiments continues the analysis of hemispheric differences in lexical representation and organization, and compares hemispheric specialization for early, preattentive stages of information processing with specialization for later, conscious processes. The fifth set completes the comparison between hemispheric specialization in the three experimental populations for more complex linguistic and nonlinguistic abilities whose model theoretical status remains to be determined.
| Mooshagian, Eric; Iacoboni, Marco; Zaidel, Eran (2009) Spatial attention and interhemispheric visuomotor integration in the absence of the corpus callosum. Neuropsychologia 47:933-7 |
| Uddin, Lucina Q; Mooshagian, Eric; Zaidel, Eran et al. (2008) Residual functional connectivity in the split-brain revealed with resting-state functional MRI. Neuroreport 19:703-9 |
| Greene, Deanna J; Barnea, Anat; Herzberg, Kristin et al. (2008) Measuring attention in the hemispheres: the lateralized attention network test (LANT). Brain Cogn 66:21-31 |
| Mooshagian, Eric; Iacoboni, Marco; Zaidel, Eran (2008) The role of task history in simple reaction time to lateralized light flashes. Neuropsychologia 46:659-64 |
| Fernandino, Leonardo; Iacoboni, Marco; Zaidel, Eran (2007) The effects of bilateral presentations on lateralized lexical decision. Brain Cogn 64:60-7 |
| de Bode, Stella; Sininger, Yvonne; Healy, Eric W et al. (2007) Dichotic listening after cerebral hemispherectomy: methodological and theoretical observations. Neuropsychologia 45:2461-6 |
| Hale, T Sigi; Zaidel, Eran; McGough, James J et al. (2006) Atypical brain laterality in adults with ADHD during dichotic listening for emotional intonation and words. Neuropsychologia 44:896-904 |
| Luders, E; Narr, K L; Zaidel, E et al. (2006) Parasagittal asymmetries of the corpus callosum. Cereb Cortex 16:346-54 |
| Aziz-Zadeh, Lisa; Koski, Lisa; Zaidel, Eran et al. (2006) Lateralization of the human mirror neuron system. J Neurosci 26:2964-70 |
| Luders, Eileen; Narr, Katherine L; Zaidel, Eran et al. (2006) Gender effects on callosal thickness in scaled and unscaled space. Neuroreport 17:1103-6 |
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