Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS020683-08
Application #
2263939
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1985-07-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Michigan State University
Department
Pharmacology
Type
Schools of Veterinary Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Rheuben, Mary B; Autio, Dawn M; Xu, You-Fen et al. (2004) Morphometric characterization of the neuromuscular junction of rodents intoxicated with 2,4-dithiobiuret: evidence that nerve terminal recycling processes contribute to muscle weakness. Toxicol Appl Pharmacol 196:266-86
Xu, You-Fen; Autio, Dawn; Rheuben, Mary B et al. (2002) Impairment of synaptic vesicle exocytosis and recycling during neuromuscular weakness produced in mice by 2,4-dithiobiuret. J Neurophysiol 88:3243-58
Xu, Y F; Atchison, W D (1996) Effects of omega-agatoxin-IVA and omega-conotoxin-MVIIC on perineurial Ca++ and Ca(++)-activated K+ currents of mouse motor nerve terminals. J Pharmacol Exp Ther 279:1229-36
Ireland, L M; Yan, C H; Nelson, L M et al. (1995) Differential effects of 2,4-dithiobiuret on the synthesis and release of acetylcholine and dopamine from rat pheochromocytoma (PC12) cells. J Pharmacol Exp Ther 275:1453-62
Spitsbergen, J M; Atchison, W D (1995) The paralytic agent 2,4-dithiobiuret decreases open time of murine skeletal muscle acetylcholine receptor channels. J Pharmacol Exp Ther 272:645-51
Williams, K D; Peterson, R E; Atchison, W D (1992) High dose refractoriness to the neuromuscular toxicity of dithiobiuret in rats. Neurotoxicology 13:331-45
Spitsbergen, J M; Atchison, W D (1991) Voltage clamp analysis reveals multiple populations of quanta released at neuromuscular junctions of rats treated with 2,4-dithiobiuret. J Pharmacol Exp Ther 256:159-63
Atchison, W D (1990) Reduced safety factor for neuromuscular transmission and abnormal quantal secretion precede neuromuscular weakness induced by dithiobiuret. Toxicol Appl Pharmacol 106:234-44
Spitsbergen, J M; Atchison, W D (1990) Acute alterations in murine neuromuscular transmission following exposure to a nonparalytic dose of dithiobiuret. Toxicol Appl Pharmacol 102:68-79
Atchison, W D (1989) Dihydropyridine-sensitive and -insensitive components of acetylcholine release from rat motor nerve terminals. J Pharmacol Exp Ther 251:672-8

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