In the present proposal, the major purpose will be to test whether there is a correspondence between animals and humans in terms of prefrontal cortex mediation of memory function. It has been proposed that the basic deficit in humans with prefrontal cortex damage is the inability to order information on a short-term temporal basis. This is based on both clinical observations and deficits on cognitive tests in which prospective functions dealing with memory for relative recency are measured. Previous research has suggested that the prefrontal cortex in rats mediates temporal structuring of information, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the prefrontal cortex in processing temporal information, suggesting a correspondence between animals and humans. In order to elaborate further on the role of the prefrontal cortex in processing temporal information, a behavioral model has been developed in rats in which one can measure a) memory for order information for a list of specific visual cues, b) memory for order information for a list of specific motor responses, c) memory for frequency, d) utilization of retrospective and prospective codes in remembering lists of spatial locations. It is proposed to use this animal model as a means of continuing the investigation of the role of prefrontal cortex in mediating temporal ordering of information.
The first aim i s to determine whether the medial prefrontal cortex in the rat mediates temporal (order) information for specific visual cues as well as for specific motor responses.
The second aim i s to determine whether the medial prefrontal cortex in the rat mediates memory for frequency.
The third aim i s to determine whether the medial prefrontal cortex is involved with retrospective and prospective coding of sequential information.
The fourth aim i s to determine possible uniqueness of function of the medial prefrontal cortex by examining the role of the orbito-insular prefrontal cortex, dorsolateral frontal cortex and parietal cortex in mediating temporal information. It is hoped that the information gleaned from these studies will provide an understanding of the frontal lobe syndrome such that a rational therapeutic intervention can be established.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS020771-05
Application #
3401341
Study Section
Biopsychology Study Section (BPO)
Project Start
1984-04-01
Project End
1990-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
Schools of Arts and Sciences
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Ragozzino, Michael E; Ragozzino, Katharine E; Mizumori, Sheri J Y et al. (2002) Role of the dorsomedial striatum in behavioral flexibility for response and visual cue discrimination learning. Behav Neurosci 116:105-15
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Ragozzino, M E; Kesner, R P (2001) The role of rat dorsomedial prefrontal cortex in working memory for egocentric responses. Neurosci Lett 308:145-8
Ragozzino, M E; Wilcox, C; Raso, M et al. (1999) Involvement of rodent prefrontal cortex subregions in strategy switching. Behav Neurosci 113:32-41
Ragozzino, M E; Detrick, S; Kesner, R P (1999) Involvement of the prelimbic-infralimbic areas of the rodent prefrontal cortex in behavioral flexibility for place and response learning. J Neurosci 19:4585-94
Ragozzino, M E; Kesner, R P (1999) The role of the agranular insular cortex in working memory for food reward value and allocentric space in rats. Behav Brain Res 98:103-12
Ragozzino, M E; Adams, S; Kesner, R P (1998) Differential involvement of the dorsal anterior cingulate and prelimbic-infralimbic areas of the rodent prefrontal cortex in spatial working memory. Behav Neurosci 112:293-303
Ragozzino, M E; Kesner, R P (1998) The effects of muscarinic cholinergic receptor blockade in the rat anterior cingulate and Prelimbic/Infralimbic cortices on spatial working memory. Neurobiol Learn Mem 69:241-57
Jackson, P A; Kesner, R P; Amann, K (1998) Memory for duration: role of hippocampus and medial prefrontal cortex. Neurobiol Learn Mem 70:328-48
Chiba, A A; Kesner, R P; Gibson, C J (1997) Memory for temporal order of new and familiar spatial location sequences: role of the medial prefrontal cortex. Learn Mem 4:311-7

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