Abstract

The proposed research is a program for an in-depth neurophysiological study of the dorsal spinocerebellar tract (DSCT) in the cat. The long term objectives of the program are to determine the role played by sensory receptors in the control of movement and posture. The DSCT is a pathway that transmits information to the cerebellum derived from sensory receptors in the muscles, joints and skin of the hind limbs.
The specific aim of this proposal is to determine what information is encoded by the DSCT for transmission to the cerebellum and how the information is encoded. The experimental design incorporates random sampling of large numbers of DSCT units to determine neuron population behavior. Quantitative data analysis is based on information theory. Principal component analysis, statistical correlations and a database management system, developed specifically for the purpose, designed to allow repeated reexamination of experimental data and protocols with different working hypotheses in a systematic and ordered manner that minimizes the need for experimental animals.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS021143-03
Application #
3401996
Study Section
Neurology B Subcommittee 1 (NEUB)
Project Start
1985-09-09
Project End
1993-08-31
Budget Start
1988-07-01
Budget End
1989-08-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Valle, M S; Bosco, G; Poppele, R E (2017) Cerebellar compartments for the processing of kinematic and kinetic information related to hindlimb stepping. Exp Brain Res 235:3437-3448
Valle, M S; Eian, J; Bosco, G et al. (2012) The organization of cortical activity in the anterior lobe of the cat cerebellum during hindlimb stepping. Exp Brain Res 216:349-65
Valle, M S; Eian, J; Bosco, G et al. (2008) Cerebellar cortical activity in the cat anterior lobe during hindlimb stepping. Exp Brain Res 187:359-72
Bosco, G; Eian, J; Poppele, R E (2006) Phase-specific sensory representations in spinocerebellar activity during stepping: evidence for a hybrid kinematic/kinetic framework. Exp Brain Res 175:83-96
Bosco, G; Eian, J; Poppele, R E (2005) Kinematic and non-kinematic signals transmitted to the cat cerebellum during passive treadmill stepping. Exp Brain Res 167:394-403
Bosco, G; Rankin, A; Poppele, R E (2003) Modulation of dorsal spinocerebellar responses to limb movement. I. Effect of serotonin. J Neurophysiol 90:3361-71
Bosco, G; Poppele, R E (2003) Modulation of dorsal spinocerebellar responses to limb movement. II. Effect of sensory input. J Neurophysiol 90:3372-83
Bosco, G; Poppele, R E (2002) Encoding of hindlimb kinematics by spinocerebellar circuitry. Arch Ital Biol 140:185-92
Poppele, R E; Bosco, G; Rankin, A M (2002) Independent representations of limb axis length and orientation in spinocerebellar response components. J Neurophysiol 87:409-22
Bosco, G; Poppele, R E (2000) Reference frames for spinal proprioception: kinematics based or kinetics based? J Neurophysiol 83:2946-55

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