Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS022153-16
Application #
2853739
Study Section
Special Emphasis Panel (ZRG1-ALTX-3 (01))
Program Officer
Kitt, Cheryl A
Project Start
1984-09-01
Project End
2003-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
16
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Xu, Q; Pichichero, M E; Simpson, L L et al. (2009) An adenoviral vector-based mucosal vaccine is effective in protection against botulism. Gene Ther 16:367-75
Ravichandran, Easwaran; Al-Saleem, Fetweh H; Ancharski, Denise M et al. (2007) Trivalent vaccine against botulinum toxin serotypes A, B, and E that can be administered by the mucosal route. Infect Immun 75:3043-54
Zeng, Mingtao; Xu, Qingfu; Elias, Md et al. (2007) Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine. Vaccine 25:7540-8
Ravichandran, Easwaran; Gong, Yujing; Al Saleem, Fetweh H et al. (2006) An initial assessment of the systemic pharmacokinetics of botulinum toxin. J Pharmacol Exp Ther 318:1343-51
Ahsan, Chowdhury R; Hajnoczky, Gyorgy; Maksymowych, Andrew B et al. (2005) Visualization of binding and transcytosis of botulinum toxin by human intestinal epithelial cells. J Pharmacol Exp Ther 315:1028-35
Maksymowych, Andrew B; Simpson, Lance L (2004) Structural features of the botulinum neurotoxin molecule that govern binding and transcytosis across polarized human intestinal epithelial cells. J Pharmacol Exp Ther 310:633-41
Simpson, Lance L; Maksymowych, Andrew B; Park, Jong-Beak et al. (2004) The role of the interchain disulfide bond in governing the pharmacological actions of botulinum toxin. J Pharmacol Exp Ther 308:857-64
Park, Jong-Beak; Simpson, Lance L (2003) Inhalational poisoning by botulinum toxin and inhalation vaccination with its heavy-chain component. Infect Immun 71:1147-54
Park, Jong-Beak; Simpson, Lance L; Anderson, Timothy D et al. (2003) Immunologic characterization of spasmodic dysphonia patients who develop resistance to botulinum toxin. J Voice 17:255-64
Simpson, L L; Maksymowych, A B; Hao, S (2001) The role of zinc binding in the biological activity of botulinum toxin. J Biol Chem 276:27034-41

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