Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022625-11
Application #
2264574
Study Section
Physiology Study Section (PHY)
Project Start
1985-09-09
Project End
1999-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pharmacology
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Nanou, Evanthia; Lee, Amy; Catterall, William A (2018) Control of Excitation/Inhibition Balance in a Hippocampal Circuit by Calcium Sensor Protein Regulation of Presynaptic Calcium Channels. J Neurosci 38:4430-4440
Qian, Hai; Patriarchi, Tommaso; Price, Jennifer L et al. (2017) Phosphorylation of Ser1928 mediates the enhanced activity of the L-type Ca2+ channel Cav1.2 by the ?2-adrenergic receptor in neurons. Sci Signal 10:
Patriarchi, Tommaso; Qian, Hai; Di Biase, Valentina et al. (2016) Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the ?2 adrenergic receptor. EMBO J 35:1330-45
Nanou, Evanthia; Scheuer, Todd; Catterall, William A (2016) Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to long-term potentiation and spatial learning. Proc Natl Acad Sci U S A 113:13209-13214
Tang, Lin; Gamal El-Din, Tamer M; Swanson, Teresa M et al. (2016) Structural basis for inhibition of a voltage-gated Ca2+ channel by Ca2+ antagonist drugs. Nature 537:117-121
Southan, Christopher; Sharman, Joanna L; Benson, Helen E et al. (2016) The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic Acids Res 44:D1054-68
Nanou, Evanthia; Yan, Jin; Whitehead, Nicholas P et al. (2016) Altered short-term synaptic plasticity and reduced muscle strength in mice with impaired regulation of presynaptic CaV2.1 Ca2+ channels. Proc Natl Acad Sci U S A 113:1068-73
Nanou, Evanthia; Sullivan, Jane M; Scheuer, Todd et al. (2016) Calcium sensor regulation of the CaV2.1 Ca2+ channel contributes to short-term synaptic plasticity in hippocampal neurons. Proc Natl Acad Sci U S A 113:1062-7
Catterall, William A (2015) Finding Channels. J Biol Chem 290:28357-73
Yan, Jin; Leal, Karina; Magupalli, Venkat G et al. (2014) Modulation of CaV2.1 channels by neuronal calcium sensor-1 induces short-term synaptic facilitation. Mol Cell Neurosci 63:124-31

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