Abstract

In recent years, a striking internal organization of the mammalian striatum has been revealed by neuroanatomical and histochemical experiments. Two forms of anatomical heterogeneity have been revealed in the striatum: patches and gradients. Recent autoradiographic studies from the principal investigator's laboratory reveal that the dopamine (D-2) receptor of the striatum shows a marked lateral-to-medial gradient, suggesting an important novel type of heterogeneity in the dopaminergic control of striatal function. Experiments are proposed to characterize and understand the basis for this D-2 heterogeneity. Specific experiments will test (1) whether the striatal D-2 heterogeneity takes the form of patches in a species (rabbit) that displays a patchy organization of acetylcholinesterase, and (2) whether the lateral-to-medial gradient of D-2 receptors in rat caudate-putamen reflects an association of this receptor subtype with cortical afferents to the striatum, intrinsic neurons, or both. Experiments that employ intrastriatal kainic acid injections in neonatal rats or adult dopamine-depleted rats are further designed to test the hypothesis of a preferential association of dopamine D-2 receptor with striatal cholinergic cells.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS022698-02
Application #
3405492
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1985-09-09
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Arts and Sciences
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

O'Dell, S J; Gross, N B; Fricks, A N et al. (2007) Running wheel exercise enhances recovery from nigrostriatal dopamine injury without inducing neuroprotection. Neuroscience 144:1141-51
Trevitt, Jennifer T; Morrow, Joseph; Marshall, John F (2005) Dopamine manipulation alters immediate-early gene response of striatal parvalbumin interneurons to cortical stimulation. Brain Res 1035:41-50
Billings, Lauren M; Marshall, John F (2004) Glutamic acid decarboxylase 67 mRNA regulation in two globus pallidus neuron populations by dopamine and the subthalamic nucleus. J Neurosci 24:3094-103
Hoover, Brian R; Marshall, John F (2004) Molecular, chemical, and anatomical characterization of globus pallidus dopamine D2 receptor mRNA-containing neurons. Synapse 52:100-13
Billings, Lauren M; Marshall, John F (2003) D2 antagonist-induced c-fos in an identified subpopulation of globus pallidus neurons by a direct intrapallidal action. Brain Res 964:237-43
Hoover, B R; Marshall, J F (2002) Further characterization of preproenkephalin mRNA-containing cells in the rodent globus pallidus. Neuroscience 111:111-25
Marshall, J F; Henry, B L; Billings, L M et al. (2001) The role of the globus pallidus D2 subfamily of dopamine receptors in pallidal immediate early gene expression. Neuroscience 105:365-78
Schuller, J J; Marshall, J F (2000) Acute immediate-early gene response to 6-hydroxydopamine infusions into the medial forebrain bundle. Neuroscience 96:51-8
McPherson, R J; Marshall, J F (2000) Substantia nigra glutamate antagonists produce contralateral turning and basal ganglia Fos expression: interactions with D1 and D2 dopamine receptor agonists. Synapse 36:194-204
LaHoste, G J; Henry, B L; Marshall, J F (2000) Dopamine D1 receptors synergize with D2, but not D3 or D4, receptors in the striatum without the involvement of action potentials. J Neurosci 20:6666-71

Showing the most recent 10 out of 56 publications