Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023039-10
Application #
2264695
Study Section
AIDS and Related Research Study Section 7 (ARRG)
Project Start
1986-07-01
Project End
1999-02-28
Budget Start
1996-05-01
Budget End
1997-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Veterinary Sciences
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Barber, Sheila A; Herbst, David S; Bullock, Brandon T et al. (2004) Innate immune responses and control of acute simian immunodeficiency virus replication in the central nervous system. J Neurovirol 10 Suppl 1:15-20
Rue, Sarah M; Roos, Jason W; Amzel, L Mario et al. (2003) Hydrogen bonding at a conserved threonine in lentivirus capsid is required for virus replication. J Virol 77:8009-18
Barber, Sheila A; Bruett, Linda; Douglass, Brian R et al. (2002) Visna virus-induced activation of MAPK is required for virus replication and correlates with virus-induced neuropathology. J Virol 76:817-28
Bruett, L; Clements, J E (2001) Functional murine leukemia virus vectors pseudotyped with the visna virus envelope show expanded visna virus cell tropism. J Virol 75:11464-73
Bruett, L; Barber, S A; Clements, J E (2000) Characterization of a membrane-associated protein implicated in visna virus binding and infection. Virology 271:132-41
Barber, S A; Bruett, L; Clements, J E (2000) Involvement of a membrane-associated serine/threonine kinase complex in cellular binding of visna virus. Virology 274:321-30
Morse, B A; Carruth, L M; Clements, J E (1999) Targeting of the visna virus tat protein to AP-1 sites: interactions with the bZIP domains of fos and jun in vitro and in vivo. J Virol 73:37-45
Craig, L E; Sheffer, D; Meyer, A L et al. (1997) Pathogenesis of ovine lentiviral encephalitis: derivation of a neurovirulent strain by in vivo passage. J Neurovirol 3:417-27
Schoborg, R V; Clements, J E (1996) Definition of the RRE binding and activation domains of the caprine arthritis encephalitis virus Rev protein. Virology 226:113-21
Carruth, L M; Morse, B A; Clements, J E (1996) The leucine domain of the visna virus Tat protein mediates targeting to an AP-1 site in the viral long terminal repeat. J Virol 70:4338-44

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