Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS023919-10
Application #
2265007
Study Section
Neurology C Study Section (NEUC)
Project Start
1987-04-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Conti-Fine, Bianca M; Milani, Monica; Wang, Wei (2008) CD4+ T cells and cytokines in the pathogenesis of acquired myasthenia gravis. Ann N Y Acad Sci 1132:193-209
Wang, Wei; Milani, Monica; Ostlie, Norma et al. (2007) C57BL/6 mice genetically deficient in IL-12/IL-23 and IFN-gamma are susceptible to experimental autoimmune myasthenia gravis, suggesting a pathogenic role of non-Th1 cells. J Immunol 178:7072-80
Milani, Monica; Ostlie, Norma; Wu, Huiyun et al. (2006) CD4+ T and B cells cooperate in the immunoregulation of Experimental Autoimmune Myasthenia Gravis. J Neuroimmunol 179:152-62
Conti-Fine, Bianca M; Milani, Monica; Kaminski, Henry J (2006) Myasthenia gravis: past, present, and future. J Clin Invest 116:2843-54
Wang, Wei; Ostlie, Norma S; Conti-Fine, Bianca M et al. (2004) The susceptibility to experimental myasthenia gravis of STAT6-/- and STAT4-/- BALB/c mice suggests a pathogenic role of Th1 cells. J Immunol 172:97-103
Ostlie, Norma; Milani, Monica; Wang, Wei et al. (2003) Absence of IL-4 facilitates the development of chronic autoimmune myasthenia gravis in C57BL/6 mice. J Immunol 170:604-12
Consogno, Giuseppe; Manici, Simona; Facchinetti, Valeria et al. (2003) Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3. Blood 101:1038-44
Yang, Huan; Goluszko, Elzbieta; David, Chella et al. (2003) Induction of myasthenia gravis in HLA transgenic mice by immunization with human acetylcholine receptors. Ann N Y Acad Sci 998:375-8
Yang, Huan; Goluszko, Elzbieta; David, Chella et al. (2002) Mapping myasthenia gravis-associated T cell epitopes on human acetylcholine receptors in HLA transgenic mice. J Clin Invest 109:1111-20
Monfardini, Cristina; Milani, Monica; Ostlie, Norma et al. (2002) Adoptive protection from experimental myasthenia gravis with T cells from mice treated nasally with acetylcholine receptor epitopes. J Neuroimmunol 123:123-34

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