Two major goals are outlined: 1. to define the spinal projections of 6 premotor areas in monkey frontal cortex; and 2. to determine input patterns from the basal ganglia and cerebellum to the premotor areas. Three series of experiments are proposed. The first series asks whether or not spinal terminations of premotor areas differ: Cortical microstimulation will be used to define borders of premotor areas, and then WGA-HRP will be injected to visualize anterograde terminal label in the spinal cord. The second series of experiments will use the anterograde transneuronal transport of herpes virus to determine the second- and third-order spinal connections of the premotor areas. The third series of experiments will determine the retrograde transneuronal pattern of label in the cerebellum and basal ganglia following cortical injections.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024328-12
Application #
2609603
Study Section
Neurology B Subcommittee 2 (NEUB)
Program Officer
Broman, Sarah H
Project Start
1986-12-01
Project End
1999-06-30
Budget Start
1997-12-01
Budget End
1999-06-30
Support Year
12
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Central New York Research Corporation
Department
Type
DUNS #
606310928
City
Syracuse
State
NY
Country
United States
Zip Code
13210
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Bostan, Andreea C; Strick, Peter L (2018) The basal ganglia and the cerebellum: nodes in an integrated network. Nat Rev Neurosci 19:338-350
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Bostan, Andreea C; Dum, Richard P; Strick, Peter L (2013) Cerebellar networks with the cerebral cortex and basal ganglia. Trends Cogn Sci 17:241-54

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