Abstract

We propose to develop relatively atraumatic study methods that may be applied to patients for determining accurately and precisely measurements of local cerebral function in terms of absolute values of circulation and metabolism. By means of emission computed tomography of appropriately chosen radioactive indicators given intravenously, tracer distributions will be quantified with three-dimensional localization. Once validated, these methods will be applied to improve understanding of basic human cerebral physiology and will be evaluated for their usefulness in enhancing the diagnosis and management of patients with cerebrovascular disease, seizure disorders, and metabolic encephalopathies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS024896-03
Application #
3409913
Study Section
(SSS)
Project Start
1986-07-01
Project End
1989-03-31
Budget Start
1988-04-01
Budget End
1989-03-31
Support Year
3
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Bohnen, Nicolaas I; Koeppe, Robert A; Minoshima, Satoshi et al. (2011) Cerebral glucose metabolic features of Parkinson disease and incident dementia: longitudinal study. J Nucl Med 52:848-55
Kuhl, David E; Koeppe, Robert A; Snyder, Scott E et al. (2006) In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses. Ann Neurol 59:13-20
Moretti, P; Lieberman, A P; Wilde, E A et al. (2004) Novel insertional presenilin 1 mutation causing Alzheimer disease with spastic paraparesis. Neurology 62:1865-8
Minoshima, Satoshi; Frey, Kirk A; Cross, Donna J et al. (2004) Neurochemical imaging of dementias. Semin Nucl Med 34:70-82
Minoshima, Satoshi; Foster, Norman L; Petrie, Eric C et al. (2002) Neuroimaging in dementia with Lewy bodies: metabolism, neurochemistry, and morphology. J Geriatr Psychiatry Neurol 15:200-9
Minoshima, S; Foster, N L; Sima, A A et al. (2001) Alzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation. Ann Neurol 50:358-65
Cross, D J; Minoshima, S; Nishimura, S et al. (2000) Three-dimensional stereotactic surface projection analysis of macaque brain PET: development and initial applications. J Nucl Med 41:1879-87
Brown-Proctor, C; Snyder, S E; Sherman, P S et al. (2000) Synthesis and in vivo evaluation of (E)-N-[(11)C]Methyl-4- (3-pyridinyl)-3-butene-1-amine ([(11)C]metanicotine) as a nicotinic receptor radioligand. Nucl Med Biol 27:415-8
Kuhl, D E; Minoshima, S; Frey, K A et al. (2000) Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex. Ann Neurol 48:391-5
Foster, N L; Minoshima, S; Johanns, J et al. (2000) PET measures of benzodiazepine receptors in progressive supranuclear palsy. Neurology 54:1768-73

Showing the most recent 10 out of 52 publications