Abstract

The goals of this proposal build from results obtained in the previous 4 years of funding during which it was observed that combinations of fetal spinal cord transplants, neurotrophin treatment, and treatment with antibodies against the myelin inhibitory protein IN-1 significantly improved both regeneration of specific descending pathways and motor behavior in neonatal spinal lesioned rats. The hypothesis on which the present proposal is based are that interventions that increase anatomical regrowth of severed axons lead to increased functional recovery and specific descending pathways are differentially affected by these treatments and underlie distinct components of the behavioral recovery. In this proposal, the effects of these treatments will be examined in adult rats with spinal cord injury, examing 1) acute thoracic, 2) acute cervical, and 3) chronic cervical injury, evaluating both anatomical and behavioral recovery.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS027054-09
Application #
2685665
Study Section
Neurology B Subcommittee 2 (NEUB)
Program Officer
Chiu, Arlene Y
Project Start
1989-04-01
Project End
2001-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Kim, Byung G; Dai, Hai-Ning; McAtee, Marietta et al. (2008) Modulation of dendritic spine remodeling in the motor cortex following spinal cord injury: effects of environmental enrichment and combinatorial treatment with transplants and neurotrophin-3. J Comp Neurol 508:473-86
Corbin, Joshua G; Haydar, Tarik F (2007) Quantum dots for neuroscience research: new tools for old problems? Nanomedicine (Lond) 2:579-81
Kim, Byung G; Dai, Hai-Ning; McAtee, Marietta et al. (2007) Labeling of dendritic spines with the carbocyanine dye DiI for confocal microscopic imaging in lightly fixed cortical slices. J Neurosci Methods 162:237-43
Slotkin, Jonathan R; Chakrabarti, Lina; Dai, Hai Ning et al. (2007) In vivo quantum dot labeling of mammalian stem and progenitor cells. Dev Dyn 236:3393-401
Richards, A Brent; Scheel, Tracy A; Wang, Kan et al. (2007) EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity. Eur J Neurosci 25:2619-28
Iarikov, Dmitri E; Kim, Byung G; Dai, Hai-Ning et al. (2007) Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injury. J Neurotrauma 24:690-702
Kim, Byung G; Dai, Hai-Ning; McAtee, Marietta et al. (2006) Remodeling of synaptic structures in the motor cortex following spinal cord injury. Exp Neurol 198:401-15
Carney, Rosalind S E; Alfonso, Teresa B; Cohen, Daniela et al. (2006) Cell migration along the lateral cortical stream to the developing basal telencephalic limbic system. J Neurosci 26:11562-74
Kim, Byung G; Dai, Hai-Ning; Lynskey, James V et al. (2006) Degradation of chondroitin sulfate proteoglycans potentiates transplant-mediated axonal remodeling and functional recovery after spinal cord injury in adult rats. J Comp Neurol 497:182-98
Lynskey, James V; Sandhu, Faheem A; Sandhu, Faheen A et al. (2006) Delayed intervention with transplants and neurotrophic factors supports recovery of forelimb function after cervical spinal cord injury in adult rats. J Neurotrauma 23:617-34

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