Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS027580-07
Application #
2266483
Study Section
Neurology A Study Section (NEUA)
Project Start
1989-08-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Dewji, Nazneen N; Mukhopadhyay, Debashis; Singer, S Jonathan (2006) An early specific cell-cell interaction occurs in the production of beta-amyloid in cell cultures. Proc Natl Acad Sci U S A 103:1540-5
Singer, S Jonathan; Dewji, Nazneen N (2006) Evidence that Perutz's double-beta-stranded subunit structure for beta-amyloids also applies to their channel-forming structures in membranes. Proc Natl Acad Sci U S A 103:1546-50
Dewji, Nazneen N (2006) Presenilin structure in mechanisms leading to Alzheimer's disease. J Alzheimers Dis 10:277-90
Dewji, N N (2005) The structure and functions of the presenilins. Cell Mol Life Sci 62:1109-19
Dewji, Nazneen N; Valdez, Dante; Singer, S J (2004) The presenilins turned inside out: implications for their structures and functions. Proc Natl Acad Sci U S A 101:1057-62
Dewji, N N; Singer, S J (1996) Specific transcellular binding between membrane proteins crucial to Alzheimer disease. Proc Natl Acad Sci U S A 93:12575-80
Dewji, N N; Do, C (1996) Heat shock factor-1 mediates the transcriptional activation of Alzheimer's beta-amyloid precursor protein gene in response to stress. Brain Res Mol Brain Res 35:325-8
Dewji, N N; Do, C; Bayney, R M (1995) Transcriptional activation of Alzheimer's beta-amyloid precursor protein gene by stress. Brain Res Mol Brain Res 33:245-53
Trejo, J; Massamiri, T; Deng, T et al. (1994) A direct role for protein kinase C and the transcription factor Jun/AP-1 in the regulation of the Alzheimer's beta-amyloid precursor protein gene. J Biol Chem 269:21682-90
Adler, M J; Coronel, C; Shelton, E et al. (1991) Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts. Proc Natl Acad Sci U S A 88:16-20

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