Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS028896-07
Application #
2267277
Study Section
Neurology B Subcommittee 2 (NEUB)
Project Start
1991-04-01
Project End
1997-08-31
Budget Start
1996-04-01
Budget End
1997-08-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Pongrac, J L; Gibbs, R B; Defranco, D B (2004) Estrogen-mediated regulation of cholinergic expression in basal forebrain neurons requires extracellular-signal-regulated kinase activity. Neuroscience 124:809-16
Gibbs, R B (2003) Effects of ageing and long-term hormone replacement on cholinergic neurones in the medial septum and nucleus basalis magnocellularis of ovariectomized rats. J Neuroendocrinol 15:477-85
Gibbs, R B (2000) Effects of gonadal hormone replacement on measures of basal forebrain cholinergic function. Neuroscience 101:931-8
Gibbs, R B (2000) Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging 21:107-16
Aggarwal, P; Gibbs, R B (2000) Estrogen replacement does not prevent the loss of choline acetyltransferase-positive cells in the basal forebrain following either neurochemical or mechanical lesions. Brain Res 882:75-85
Gibbs, R B (1999) Estrogen replacement enhances acquisition of a spatial memory task and reduces deficits associated with hippocampal muscarinic receptor inhibition. Horm Behav 36:222-33
Gibbs, R B (1999) Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain. Brain Res 844:20-7
Gibbs, R B; Burke, A M; Johnson, D A (1998) Estrogen replacement attenuates effects of scopolamine and lorazepam on memory acquisition and retention. Horm Behav 34:112-25
Gibbs, R B (1998) Impairment of basal forebrain cholinergic neurons associated with aging and long-term loss of ovarian function. Exp Neurol 151:289-302
Gibbs, R B; Hashash, A; Johnson, D A (1997) Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats. Brain Res 749:143-6

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