Stroke remains a major public health problem with a disproportionate impact on Blacks and Hispanics. Studies in Northern Manhattan have demonstrated that Blacks and Hispanics have a greater stroke incidence and more frequently have intracranial atherosclerotic stroke than whites. The reasons for this race-ethnic disparity are not entirely clear. Cross-sectional and case-control studies have identified racial-ethnic differences in modifiable stroke risk factors, however definition of exposures in these studies has been looked upon as prone to measurement errors because of retrospective recall and selection biases.
The Aims of this competitive continuation application are to evaluate the reasons for race-ethnic differences in stroke incidence, confirm the case-control findings of the protective effects of leisure-time physical activity, alcohol use, and HDL-cholesterol, and test new hypotheses regarding HDL subpopulations and homocysteine. To accomplish these Aims a population-based, prospective cohort study is proposed. Community subjects free of stroke will be ascertained through dual frame random-digit dialing and a cohort of 3000 White, Black and Hispanic adults over age 55 living in the same tri-ethnic community of Northern Manhattan will be followed. Approximately 1400 subjects will have been enrolled by the time this application begins and another 1600 subjects will be enrolled in the first 2 years. Socioeconomic, demographic, and risk factor data including dietary assessments will be gathered through direct interview of the subject or family. At baseline, all subjects will have measurements of anthropometric indices, blood pressure, and EKG, and blood will be drawn for total homocysteine, related metabolites, B12, folate, creatinine, and lipid profiles (cholesterol, LDL, triglyceride, HDL, and HDL subpopulations). Subjects will be followed by annual telephone interviews to ascertain stroke, myocardial infarction, and death. In-person assessment will be done for all subjects with suspected outcome events and a 10% random sample of the cohort. Community stroke surveillance will be maintained to insure stroke detection among the cohort. Kaplan-Meier curves and Cox-proportional hazards models will be used to calculate adjusted relative stroke incidence rates and to evaluate the dependence of the exposures of interest on stroke adjusting for age, gender, race-ethnicity, socioeconomic status and other risk factors. This study will be the first prospective cohort study of stroke to focus on risk factors in Whites, Blacks and Hispanics living in the same community and will help fill the gaps in our knowledge of the epidemiology of stroke in minority populations.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS029993-06
Application #
2468311
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Marler, John R
Project Start
1993-01-07
Project End
2002-11-30
Budget Start
1998-01-02
Budget End
1998-11-30
Support Year
6
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Neurology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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Della-Morte, David; Dong, Chuanhui; Markert, Matthew S et al. (2018) Carotid Intima-Media Thickness Is Associated With White Matter Hyperintensities: The Northern Manhattan Study. Stroke 49:304-311
Della-Morte, David; Gardener, Hannah; Dong, Chuanhui et al. (2018) Association Between Carotid Artery Function and Structure in the Northern Manhattan Study. Front Neurol 9:246
Willey, Joshua Z; Moon, Yeseon P; Dhamoon, Mandip S et al. (2018) Regional Subclinical Cerebrovascular Disease Is Associated with Balance in an Elderly Multi-Ethnic Population. Neuroepidemiology 51:57-63
Dhamoon, Mandip S; Cheung, Ying-Kuen; Bagci, Ahmet et al. (2018) Periventricular White Matter Hyperintensities and Functional Decline. J Am Geriatr Soc 66:113-119
Dueker, Nicole D; Guo, Shengru; Beecham, Ashley et al. (2018) Sequencing of Linkage Region on Chromosome 12p11 Identifies PKP2 as a Candidate Gene for Left Ventricular Mass in Dominican Families. G3 (Bethesda) 8:659-668
Kulick, Erin R; Wellenius, Gregory A; Boehme, Amelia K et al. (2018) Residential Proximity to Major Roadways and Risk of Incident Ischemic Stroke in NOMAS (The Northern Manhattan Study). Stroke 49:835-841
Baird, Stacy W; Jin, Zhezhen; Okajima, Kazue et al. (2018) Relationship between body mass and ambulatory blood pressure: comparison with office blood pressure measurement and effect of treatment. J Hum Hypertens 32:122-128
Dhamoon, Mandip S; Cheung, Ying-Kuen; DeRosa, Janet T et al. (2018) Association Between Subclinical Brain Infarcts and Functional Decline Trajectories. J Am Geriatr Soc 66:2144-2150
Ahn, Soohyun; Lim, Johan; Paik, Myunghee Cho et al. (2018) Cox model with interval-censored covariate in cohort studies. Biom J 60:797-814

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