Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS030808-05A2
Application #
6096998
Study Section
Special Emphasis Panel (ZRG1-MDCN-3 (01))
Program Officer
Jacobs, Margaret
Project Start
1994-03-05
Project End
2000-07-31
Budget Start
2000-04-01
Budget End
2000-07-31
Support Year
5
Fiscal Year
2000
Total Cost
$37,510
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Physiology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Bali, Moez; Akabas, Myles H (2012) Gating-induced conformational rearrangement of the ýý-aminobutyric acid type A receptor ýý-ýý subunit interface in the membrane-spanning domain. J Biol Chem 287:27762-70
Collins, Ben; Kane, Elizabeth A; Reeves, David C et al. (2012) Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron 74:706-18
McKinnon, Nicole K; Bali, Moez; Akabas, Myles H (2012) Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization. PLoS One 7:e35563
McKinnon, Nicole K; Reeves, David C; Akabas, Myles H (2011) 5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals. J Gen Physiol 138:453-66
Parikh, Rishi B; Bali, Moez; Akabas, Myles H (2011) Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility. J Biol Chem 286:14098-109
Dahdal, David; Reeves, David C; Ruben, Marc et al. (2010) Drosophila pacemaker neurons require g protein signaling and GABAergic inputs to generate twenty-four hour behavioral rhythms. Neuron 68:964-77
Bali, Moez; Jansen, Michaela; Akabas, Myles H (2009) GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci 29:3083-92
Jansen, Michaela; Rabe, Holger; Strehle, Axelle et al. (2008) Synthesis of GABAA receptor agonists and evaluation of their alpha-subunit selectivity and orientation in the GABA binding site. J Med Chem 51:4430-48
Zhao, Rongbao; Qiu, Andong; Tsai, Eugenia et al. (2008) The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharmacol 74:854-62
Jansen, Michaela; Bali, Moez; Akabas, Myles H (2008) Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop. J Gen Physiol 131:137-46

Showing the most recent 10 out of 36 publications