This is a competing continuation applicaiton for investigating the neurobiological foundations of spatial orientation (directed sensory attention) in the healthy and injured human brain. The investigations proposed in this application will revolve around a unified approach to account for the behavioral and anatomical heterogeneity of hemispatial neglect. Acoording to this approach, the anatomical substrate of spatial attention takes the form of a distributed, large-scale network with three monosynaptically interconnected cortical components (frontal, parietal, and cingulate) each of which makes a different contribution to spatial orientation. Damage to components of this network yield the various manifestations of hemispatial neglect. Our goal is to characterize the detail organization of this network its hemispheric dominance patterns, and its relationship to hemispatial neglect. To this end, we propose to continue the computerized phschophysical testing of an unselected sample of patients with focal strokes and to initiate new functional MRI studies in young, healthy volunteers. We have chosen this two-pronged approach because of the complementary nature of studying cognitive deficits by functional imaging and focal lesion analysis. Hemispatial neglect is a common and devastating consequence of brain injury. Understanding the organization of the associated neural network will be important in designing methods of treatment and rehabilitation. In addition, since the large-scale network approach which has shaped the hypotheses for this project is relevant to the organization of other cognitive domains, a clearer understanding of the neural substrate of spatial orientation is likely to provide considerable insights into the cerebral representation of other cognitive functions.
| Hastings, William D; Anderson, David E; Kassam, Nasim et al. (2009) TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol 39:2492-501 |
| Mohanty, Aprajita; Egner, Tobias; Monti, Jim M et al. (2009) Search for a threatening target triggers limbic guidance of spatial attention. J Neurosci 29:10563-72 |
| Summerfield, Christopher; Trittschuh, Emily H; Monti, Jim M et al. (2008) Neural repetition suppression reflects fulfilled perceptual expectations. Nat Neurosci 11:1004-6 |
| Mohanty, Aprajita; Gitelman, Darren R; Small, Dana M et al. (2008) The spatial attention network interacts with limbic and monoaminergic systems to modulate motivation-induced attention shifts. Cereb Cortex 18:2604-13 |
| O'Reilly, Jill X; Mesulam, M Marsel; Nobre, Anna Christina (2008) The cerebellum predicts the timing of perceptual events. J Neurosci 28:2252-60 |
| Cicek, Metehan; Gitelman, Darren; Hurley, Robert S E et al. (2007) Anatomical physiology of spatial extinction. Cereb Cortex 17:2892-8 |
| Molenberghs, Pascal; Mesulam, Marsel M; Peeters, Ronald et al. (2007) Remapping attentional priorities: differential contribution of superior parietal lobule and intraparietal sulcus. Cereb Cortex 17:2703-12 |
| Rosler, Alexander; Mapstone, Mark; Hays-Wicklund, Alissa et al. (2005) The ""zoom lens"" of focal attention in visual search: changes in aging and Alzheimer's disease. Cortex 41:512-9 |
| Small, Dana M; Gitelman, Darren; Simmons, Katharine et al. (2005) Monetary incentives enhance processing in brain regions mediating top-down control of attention. Cereb Cortex 15:1855-65 |
| Paller, Ken A; Ranganath, Charan; Gonsalves, Brian et al. (2003) Neural correlates of person recognition. Learn Mem 10:253-60 |
Showing the most recent 10 out of 24 publications
