Abstract

This Project will evaluate the effectiveness of cytosine arabinoside for treatment of biopsy proven progressive multifocal leukoencephalopathy in subjects with human immunodeficiency virus infection. A three arm study comparing best possible anti-retroviral therapy with either intravenous ARA-C therapy administered through an Ommaya reservoir. Twenty patients will be randomized to each arm of the study. The primary endpoint is death within 24 weeks. Secondary end points will be neurologic deterioration as indicated by neurologic examination and deterioration in Karnofsky Performance Scores.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS032228-05
Application #
6112481
Study Section
Project Start
1999-05-01
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Lee, Anthony J; Bosch, Ronald J; Evans, Scott R et al. (2015) Patterns of peripheral neuropathy in ART-naïve patients initiating modern ART regimen. J Neurovirol 21:210-8
Sacktor, Ned; Miyahara, Sachiko; Evans, Scott et al. (2014) Impact of minocycline on cerebrospinal fluid markers of oxidative stress, neuronal injury, and inflammation in HIV-seropositive individuals with cognitive impairment. J Neurovirol 20:620-6
Longbrake, Erin E; Ances, Beau M; Viets, Ryan B et al. (2013) Susac syndrome in a patient with human immunodeficiency virus infection. J Neurovirol 19:270-3
Zhang, Xinyan; Tierney, Camlin; Albrecht, Mary et al. (2013) Discordant associations between SLCO1B1 521T?C and plasma levels of ritonavir-boosted protease inhibitors in AIDS clinical trials group study A5146. Ther Drug Monit 35:209-16
Chen, Huichao; Clifford, David B; Deng, Lijuan et al. (2013) Peripheral neuropathy in ART-experienced patients: prevalence and risk factors. J Neurovirol 19:557-64
Nakasujja, Noeline; Miyahara, Sachiko; Evans, Scott et al. (2013) Randomized trial of minocycline in the treatment of HIV-associated cognitive impairment. Neurology 80:196-202
Harrison, Taylor; Miyahara, Sachiko; Lee, Anthony et al. (2013) Experience and challenges presented by a multicenter crossover study of combination analgesic therapy for the treatment of painful HIV-associated polyneuropathies. Pain Med 14:1039-47
Nguyen, Anh; Rossi, Steven; Croteau, David et al. (2013) Etravirine in CSF is highly protein bound. J Antimicrob Chemother 68:1161-8
Evans, Scott R; Lee, Anthony J; Ellis, Ronald J et al. (2012) HIV peripheral neuropathy progression: protection with glucose-lowering drugs? J Neurovirol 18:428-33
Phan-Ba, Rémy; Lommers, Emilie; Tshibanda, Luaba et al. (2012) MRI preclinical detection and asymptomatic course of a progressive multifocal leucoencephalopathy (PML) under natalizumab therapy. J Neurol Neurosurg Psychiatry 83:224-6

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