Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS032534-01A1
Application #
2270800
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Program Officer
Marler, John R
Project Start
1996-05-01
Project End
1999-03-31
Budget Start
1996-05-01
Budget End
1997-03-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Zhang, XiChun; Kainz, Vanessa; Zhao, Jun et al. (2013) Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors. Ann Neurol 73:741-50
Levy, Dan; Kainz, Vanessa; Burstein, Rami et al. (2012) Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun 26:311-7
Zhang, Xi-Chun; Kainz, Vanessa; Jakubowski, Moshe et al. (2009) Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett 452:33-6
Zhang, X-C; Levy, D (2008) Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia 28:276-84
Levy, Dan; Burstein, Rami; Kainz, Vanessa et al. (2007) Mast cell degranulation activates a pain pathway underlying migraine headache. Pain 130:166-76
Zhang, Xi-Chun; Strassman, Andrew M; Burstein, Rami et al. (2007) Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther 322:806-12
Strassman, Andrew M; Levy, Dan (2006) Response properties of dural nociceptors in relation to headache. J Neurophysiol 95:1298-306
Levy, Dan; Burstein, Rami; Strassman, Andrew M (2005) Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol 58:698-705
Strassman, Andrew M; Levy, Dan (2004) The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons. Neuroreport 15:1409-12
Strassman, Andrew M; Weissner, Wendi; Williams, Molly et al. (2004) Axon diameters and intradural trajectories of the dural innervation in the rat. J Comp Neurol 473:364-76

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