Abstract

The overall goal of the research proposed in this application is to determine the spatiotemporal patterns of functional activation of cortical areas during performance of specific perceptual-motor cognitive tasks, as revealed by high field strength (4 Tesla) magnetic resonance imaging (4T- mRI). Healthy human subjects will be studied. The tasks are designed to test specific hypotheses of how two major classes of cognitive processes, including mental rotation and memory scanning, are represented in the brain. The potential achievement of these objectives is within reach, due to the high spatial and temporal resolution afforded by the 4T-MRI.
The specific aims are to (a) identify the areas involved during mental rotation and memory scanning, and (b) test the hypotheses that these cognitive processes involve (i) the sequential activation of specific cortical areas and (ii) the activation of certain common cortical areas. It is expected that these studies will partially elucidate the dynamical neural correlates involved in these two different kinds of cognitive processes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
1R01NS032919-01
Application #
2271424
Study Section
Special Emphasis Panel (SRC (22))
Project Start
1994-07-15
Project End
1997-04-30
Budget Start
1994-07-15
Budget End
1995-04-30
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Physiology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Lewis, Scott M; Christova, Peka; Jerde, Trenton A et al. (2012) A compact and realistic cerebral cortical layout derived from prewhitened resting-state fMRI time series: Cherniak's adjacency rule, size law, and metamodule grouping upheld. Front Neuroanat 6:36
Christova, P; Lewis, S M; Jerde, T A et al. (2011) True associations between resting fMRI time series based on innovations. J Neural Eng 8:046025
Tzagarakis, Charidimos; Jerde, Trenton A; Lewis, Scott M et al. (2009) Cerebral cortical mechanisms of copying geometrical shapes: a multidimensional scaling analysis of fMRI patterns of activation. Exp Brain Res 194:369-80
Christova, Peka S; Lewis, Scott M; Tagaris, Georgios A et al. (2008) A voxel-by-voxel parametric fMRI study of motor mental rotation: hemispheric specialization and gender differences in neural processing efficiency. Exp Brain Res 189:79-90
Georgopoulos, Apostolos P; Karageorgiou, Elissaios (2008) Neurostatistics: applications, challenges and expectations. Stat Med 27:407-17
Lewis, Scott M; Jerde, Trenton A; Tzagarakis, Charidimos et al. (2005) Logarithmic transformation for high-field BOLD fMRI data. Exp Brain Res 165:447-53
Gourtzelidis, Pavlos; Tzagarakis, Charidimos; Lewis, Scott M et al. (2005) Mental maze solving: directional fMRI tuning and population coding in the superior parietal lobule. Exp Brain Res 165:273-82
Lewis, Scott M; Jerde, Trenton A; Tzagarakis, Charidimos et al. (2003) Cerebellar activation during copying geometrical shapes. J Neurophysiol 90:3874-87
Georgopoulos, Apostolos P (2002) Cognitive motor control: spatial and temporal aspects. Curr Opin Neurobiol 12:678-83
Georgopoulos, A P; Whang, K; Georgopoulos, M A et al. (2001) Functional magnetic resonance imaging of visual object construction and shape discrimination : relations among task, hemispheric lateralization, and gender. J Cogn Neurosci 13:72-89

Showing the most recent 10 out of 25 publications