Abstract

Fruitless (fru) is the first gene in a branch of the Drosophila sex determination hierarchy. Fru appears to govern all, or nearly all, aspects of male species-specific sexual behavior. This proposal focuses on several aspects of (1) how fru acts to lay down the potential for a complex behavior in the CNS, and (2) how that behavior is controlled by the CNS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS033352-06
Application #
2891945
Study Section
Neurology C Study Section (NEUC)
Program Officer
Finkelstein, Robert
Project Start
1994-09-15
Project End
2003-05-31
Budget Start
1999-06-01
Budget End
2000-05-31
Support Year
6
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Latham, Kristin L; Liu, Ying-Show; Taylor, Barbara J (2013) A small cohort of FRU(M) and Engrailed-expressing neurons mediate successful copulation in Drosophila melanogaster. BMC Neurosci 14:57
Villella, Adriana; Hall, Jeffrey C (2008) Neurogenetics of courtship and mating in Drosophila. Adv Genet 62:67-184
Hall, Jeffrey C (2007) Issues revolving round the regulation of reproductively related genes in Drosophila. J Neurogenet 21:75-103
Villella, Adriana; Peyre, Jean-Baptiste; Aigaki, Toshiro et al. (2006) Defective transfer of seminal-fluid materials during matings of semi-fertile fruitless mutants in Drosophila. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192:1253-69
Shirangi, Troy R; Taylor, Barbara J; McKeown, Michael (2006) A double-switch system regulates male courtship behavior in male and female Drosophila melanogaster. Nat Genet 38:1435-9
Billeter, Jean-Christophe; Villella, Adriana; Allendorfer, Jane B et al. (2006) Isoform-specific control of male neuronal differentiation and behavior in Drosophila by the fruitless gene. Curr Biol 16:1063-76
Ditch, Lynn M; Shirangi, Troy; Pitman, Jeffrey L et al. (2005) Drosophila retained/dead ringer is necessary for neuronal pathfinding, female receptivity and repression of fruitless independent male courtship behaviors. Development 132:155-64
Villella, Adriana; Ferri, Sarah L; Krystal, Jonathan D et al. (2005) Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship. Proc Natl Acad Sci U S A 102:16550-7
Song, Ho-Juhn; Taylor, Barbara J (2003) fruitless gene is required to maintain neuronal identity in evenskipped-expressing neurons in the embryonic CNS of Drosophila. J Neurobiol 55:115-33
Hall, Jeffrey C (2003) A neurogeneticist's manifesto. J Neurogenet 17:1-90

Showing the most recent 10 out of 20 publications