The proposed studies will investigate how growth factors induce directed migration of neural precursors. These investigations of polarity and migration will lead to approaches for restricting the extensive migration of malignant brain tumor cells that arise from neural precursors. In addition these studies will explain why errors in migration predispose to defects in brain circuitry in neuropsychiatric disorders such as dyslexia and autism.
Zhou, Pengcheng; Alfaro, Jose; Chang, Eun Hyuk et al. (2011) Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis. Dev Cell 20:610-22 |
Gruber-Olipitz, Mariella; Segal, Rosalind A (2009) Live or let die: CCM2 provides the link. Neuron 63:559-60 |
Chan, Jennifer A; Balasubramanian, Srividya; Witt, Rochelle M et al. (2009) Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses. Nat Neurosci 12:409-17 |
Zhou, Pengcheng; Porcionatto, Marimelia; Pilapil, Mariecel et al. (2007) Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors. Neuron 55:53-68 |
Choi, Yoojin; Borghesani, Paul R; Chan, Jennifer A et al. (2005) Migration from a mitogenic niche promotes cell-cycle exit. J Neurosci 25:10437-45 |
Carter, Alexandre R; Berry, Erin M; Segal, Rosalind A (2003) Regional expression of p75NTR contributes to neurotrophin regulation of cerebellar patterning. Mol Cell Neurosci 22:1-13 |
Kim, John Y H; Nelson, Aaron L; Algon, Sibel A et al. (2003) Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice. Dev Biol 263:50-66 |
Segal, Rosalind A (2003) Selectivity in neurotrophin signaling: theme and variations. Annu Rev Neurosci 26:299-330 |
Rubin, Joshua B; Segal, Rosalind A (2003) Growth, survival and migration: the Trk to cancer. Cancer Treat Res 115:1-18 |
Borghesani, Paul R; Peyrin, Jean Michel; Klein, Robyn et al. (2002) BDNF stimulates migration of cerebellar granule cells. Development 129:1435-42 |
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