Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS038486-10
Application #
7432477
Study Section
Biophysical Chemistry Study Section (BBCB)
Program Officer
Mamounas, Laura
Project Start
1999-02-01
Project End
2010-01-31
Budget Start
2008-05-01
Budget End
2010-01-31
Support Year
10
Fiscal Year
2008
Total Cost
$242,925
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Seegar, Tom C M; Killingsworth, Lauren B; Saha, Nayanendu et al. (2017) Structural Basis for Regulated Proteolysis by the ?-Secretase ADAM10. Cell 171:1638-1648.e7
Atapattu, Lakmali; Saha, Nayanendu; Chheang, Chanly et al. (2016) An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med 213:1741-57
Goldgur, Yehuda; Susi, Petri; Karelehto, Eveliina et al. (2014) Generation and characterization of a single-chain anti-EphA2 antibody. Growth Factors 32:214-22
Barton, William A; Dalton, Annamarie C; Seegar, Tom C M et al. (2014) Tie2 and Eph receptor tyrosine kinase activation and signaling. Cold Spring Harb Perspect Biol 6:
Nikolov, Dimitar B; Xu, Kai; Himanen, Juha P (2014) Homotypic receptor-receptor interactions regulating Eph signaling. Cell Adh Migr 8:360-5
Paavilainen, Sari; Grandy, David; Karelehto, Eveliina et al. (2013) High-level expression of a full-length Eph receptor. Protein Expr Purif 92:112-8
Ferluga, Sara; Hantgan, Roy; Goldgur, Yehuda et al. (2013) Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase. J Biol Chem 288:18448-57
Xu, Kai; Tzvetkova-Robev, Dorothea; Xu, Yan et al. (2013) Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc Natl Acad Sci U S A 110:14634-9
Xu, Kai; Xu, Yan; Rajashankar, Kanagalaghatta R et al. (2013) Crystal structures of Lgr4 and its complex with R-spondin1. Structure 21:1683-9
Nikolov, Dimitar B; Xu, Kai; Himanen, Juha P (2013) Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation. Biochim Biophys Acta 1834:2160-5

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