Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS038650-04
Application #
6499434
Study Section
Special Emphasis Panel (ZRG1-BDCN-3 (01))
Program Officer
Leblanc, Gabrielle G
Project Start
1999-03-01
Project End
2003-01-31
Budget Start
2002-02-01
Budget End
2003-01-31
Support Year
4
Fiscal Year
2002
Total Cost
$391,076
Indirect Cost
Name
Ohio State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Arnold, W; McGovern, Vicki L; Sanchez, Benjamin et al. (2016) The neuromuscular impact of symptomatic SMN restoration in a mouse model of spinal muscular atrophy. Neurobiol Dis 87:116-23
Butchbach, Matthew E R; Lumpkin, Casey J; Harris, Ashlee W et al. (2016) Protective effects of butyrate-based compounds on a mouse model for spinal muscular atrophy. Exp Neurol 279:13-26
McGovern, Vicki L; Iyer, Chitra C; Arnold, W David et al. (2015) SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMN?7 mouse model of SMA. Hum Mol Genet 24:5524-41
Iyer, Chitra C; McGovern, Vicki L; Murray, Jason D et al. (2015) Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMN?7 mouse model of SMA. Hum Mol Genet 24:6160-73
Butchbach, Matthew E R; Singh, Jasbir; Gurney, Mark E et al. (2014) The effect of diet on the protective action of D156844 observed in spinal muscular atrophy mice. Exp Neurol 256:1-6
Arnold, W David; Burghes, Arthur H M (2013) Spinal muscular atrophy: development and implementation of potential treatments. Ann Neurol 74:348-62
Ruggiu, Matteo; McGovern, Vicki L; Lotti, Francesco et al. (2012) A role for SMN exon 7 splicing in the selective vulnerability of motor neurons in spinal muscular atrophy. Mol Cell Biol 32:126-38
Le, Thanh T; McGovern, Vicki L; Alwine, Isaac E et al. (2011) Temporal requirement for high SMN expression in SMA mice. Hum Mol Genet 20:3578-91
Butchbach, Matthew E R; Singh, Jasbir; Thorsteinsdóttir, Margrét et al. (2010) Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy. Hum Mol Genet 19:454-67
Bevan, Adam K; Hutchinson, Kirk R; Foust, Kevin D et al. (2010) Early heart failure in the SMNDelta7 model of spinal muscular atrophy and correction by postnatal scAAV9-SMN delivery. Hum Mol Genet 19:3895-905

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