Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS039084-03S1
Application #
6457139
Study Section
Special Emphasis Panel (ZRG1 (01))
Program Officer
Murphy, Diane
Project Start
1999-07-01
Project End
2003-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
3
Fiscal Year
2001
Total Cost
$50,000
Indirect Cost

  Institution

Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Bernstein, Alison I; O'Malley, Karen L (2013) MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death. Toxicol Lett 219:93-8
Pandey, Neeraj; Fahey, Mark T; Jong, Yuh-Jiin I et al. (2012) Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death. PLoS One 7:e45149
Lu, Xi; Kim-Han, Jeong S; O'Malley, Karen L et al. (2012) A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons. J Neurosci Methods 209:35-9
Antenor-Dorsey, Jo Ann V; O'Malley, Karen L (2012) WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity. Mol Neurodegener 7:5
Kim-Han, Jeong Sook; Antenor-Dorsey, Jo Ann; O'Malley, Karen L (2011) The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons. J Neurosci 31:7212-21
Bernstein, Alison I; Garrison, Sean P; Zambetti, Gerard P et al. (2011) 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death. Mol Neurodegener 6:2
Kim-Han, Jeong Sook; O'Malley, Karen L (2007) Cell stress induced by the parkinsonian mimetic, 6-hydroxydopamine, is concurrent with oxidation of the chaperone, ERp57, and aggresome formation. Antioxid Redox Signal 9:2255-64
Hasbani, Daphne M; O'Malley, Karen L (2006) Wld(S) mice are protected against the Parkinsonian mimetic MPTP. Exp Neurol 202:93-9
Holtz, William A; Turetzky, Jay M; Jong, Yuh-Jiin I et al. (2006) Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics. J Neurochem 99:54-69
Holtz, William A; Turetzky, Jay M; O'Malley, Karen L (2005) Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death. Antioxid Redox Signal 7:639-48

Showing the most recent 10 out of 15 publications