Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS041617-09
Application #
7418255
Study Section
Cell Development and Function Integrated Review Group (CDF)
Program Officer
Porter, John D
Project Start
2001-05-01
Project End
2010-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
9
Fiscal Year
2008
Total Cost
$320,605
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Matera, A Gregory; Wang, Zefeng (2014) A day in the life of the spliceosome. Nat Rev Mol Cell Biol 15:108-21
Praveen, Kavita; Wen, Ying; Gray, Kelsey M et al. (2014) SMA-causing missense mutations in survival motor neuron (Smn) display a wide range of phenotypes when modeled in Drosophila. PLoS Genet 10:e1004489
Garcia, Eric L; Lu, Zhipeng; Meers, Michael P et al. (2013) Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes. RNA 19:1510-6
Praveen, Kavita; Wen, Ying; Matera, A Gregory (2012) A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep 1:624-31
Gonsalvez, Graydon B; Rajendra, T K; Wen, Ying et al. (2010) Sm proteins specify germ cell fate by facilitating oskar mRNA localization. Development 137:2341-51
Fuentes, Jennifer L; Strayer, Molly S; Matera, A Gregory (2010) Molecular determinants of survival motor neuron (SMN) protein cleavage by the calcium-activated protease, calpain. PLoS One 5:e15769
Walker, Michael P; Tian, Liping; Matera, A Gregory (2009) Reduced viability, fertility and fecundity in mice lacking the cajal body marker protein, coilin. PLoS One 4:e6171
Shpargel, Karl B; Praveen, Kavita; Rajendra, T K et al. (2009) Gemin3 is an essential gene required for larval motor function and pupation in Drosophila. Mol Biol Cell 20:90-101
Liu, Ji-Long; Wu, Zheng'an; Nizami, Zehra et al. (2009) Coilin is essential for Cajal body organization in Drosophila melanogaster. Mol Biol Cell 20:1661-70
Matera, A Gregory; Izaguire-Sierra, Mario; Praveen, Kavita et al. (2009) Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? Dev Cell 17:639-47

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