The proposed research will determine the effects of environmental and life history constraints upon reproduction in common marmosets (Callithrix jacchus).
Specific Aim 1 will define the relation between maternal condition and reproductive investment through energy restrictions during gestation or lactation. Based on our preliminary findings, we expect to generate intrauterine growth retardation with minimal change in maternal condition -that is, mothers will sacrifice fetal growth to retain maternal state. We will also be testing the hypothesis that """"""""poor"""""""" mothering in multiparous females is the results of """"""""poor"""""""" infants (i.e. infants that are small or have an atypical behavioral repertoire). Energy-restriction in the post-partum period is expected to result in more dilute milk and earlier weaning.
Specific Aim 2 will define normal calcium metabolism during lactation and determine the effects of calcium restriction on calcium metabolism, milk intake, lactation and bone health in marmosets. This study will indicate whether marmosets might be a useful model for the study of maternal bone health in women, particularly relative to calcium restriction.
Specific Aim 3 will define the relation between maternal age, fertility, and survival using a large demographic database. Such information can be used to better define long-term captive propagation. The results will also be useful for defining marmosets as models of life history effects on reproduction and maternal health.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR002022-20
Application #
6639843
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Harding, John D
Project Start
1992-09-01
Project End
2005-05-31
Budget Start
2003-06-01
Budget End
2005-05-31
Support Year
20
Fiscal Year
2003
Total Cost
$257,359
Indirect Cost
Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Power, Michael L; Dittus, Wolfgang P J (2017) Vitamin D status in wild toque macaques (Macaca sinica) in Sri Lanka. Am J Primatol 79:
Banton, Sophia A; Soltow, Quinlyn A; Liu, Ken H et al. (2016) Plasma Metabolomics of Common Marmosets (Callithrix jacchus) to Evaluate Diet and Feeding Husbandry. J Am Assoc Lab Anim Sci 55:137-46
Rutherford, Julienne N; deMartelly, Victoria A; Layne Colon, Donna G et al. (2014) Developmental origins of pregnancy loss in the adult female common marmoset monkey (Callithrix jacchus). PLoS One 9:e96845
Tardif, Suzette D; Power, Michael L; Ross, Corinna N et al. (2013) Body mass growth in common marmosets: toward a model of pediatric obesity. Am J Phys Anthropol 150:21-8
Jarcho, Michael R; Power, Michael L; Layne-Colon, Donna G et al. (2013) Digestive efficiency mediated by serum calcium predicts bone mineral density in the common marmoset (Callithrix jacchus). Am J Primatol 75:153-60
Rutherford, Julienne N (2012) Toward a nonhuman primate model of fetal programming: phenotypic plasticity of the common marmoset fetoplacental complex. Placenta 33 Suppl 2:e35-9
Rutherford, Julienne N (2009) Fetal signaling through placental structure and endocrine function: illustrations and implications from a nonhuman primate model. Am J Hum Biol 21:745-53
Rutherford, Julienne N; Eklund, Amy; Tardif, Suzette (2009) Placental insulin-like growth factor II (IGF-II) and its relation to litter size in the common marmoset monkey (Callithrix jacchus). Am J Primatol 71:969-75
Rutherford, J N; Tardif, S D (2009) Developmental plasticity of the microscopic placental architecture in relation to litter size variation in the common marmoset monkey (Callithrix jacchus). Placenta 30:105-10
Power, Michael L; Verona, Carlos Eduardo; Ruiz-Miranda, Carlos et al. (2008) The composition of milk from free-living common marmosets (Callithrix jacchus) in Brazil. Am J Primatol 70:78-83

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