Funds are requested to organize a meeting of investigators of all case-control studies of epithelial ovarian carcinoma conducted in the United States since 1974. The goals of this meeting are: to explore the feasibility of a collaborative analysis of the data sets produced by these studies; and if such an analysis is deemed feasible, to outline a plan for conducting it. Issues to be discussed include: criteria for including studies in the analysis; criteria for including subjects within a study; selection of variables to be examined; a common coding scheme for variables; reproducibility of histopathologic reports; and statistical methods. Among the potential benefits of a combined analysis are: new findings inaccessible to any one data set; new hypotheses about causal mechanisms for ovarian cancer that arise from ongoing discussions among the nation's most knowledgeable investigators; and new statistical methods for combining data sets with utility for other joint investigations of infrequently occurring chronic diseases. The low cost of conducting such an analysis compares favorably with its potential for increasing the value of data that has been collected at great cost.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Research Grants (R03)
Project #
1R03CA043689-01
Application #
3422817
Study Section
(SRC)
Project Start
1986-09-30
Project End
1987-09-29
Budget Start
1986-09-30
Budget End
1987-09-29
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
John, E M; Whittemore, A S; Harris, R et al. (1993) Characteristics relating to ovarian cancer risk: collaborative analysis of seven U.S. case-control studies. Epithelial ovarian cancer in black women. Collaborative Ovarian Cancer Group. J Natl Cancer Inst 85:142-7
Whittemore, A S; Harris, R; Itnyre, J (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer Group. Am J Epidemiol 136:1184-203
Harris, R; Whittemore, A S; Itnyre, J (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. III. Epithelial tumors of low malignant potential in white women. Collaborative Ovarian Cancer Group. Am J Epidemiol 136:1204-11
Whittemore, A S; Harris, R; Itnyre, J (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. IV. The pathogenesis of epithelial ovarian cancer. Collaborative Ovarian Cancer Group. Am J Epidemiol 136:1212-20
Horn-Ross, P L; Whittemore, A S; Harris, R et al. (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. VI. Nonepithelial cancers among adults. Collaborative Ovarian Cancer Group. Epidemiology 3:490-5
Whittemore, A S; Harris, R; Itnyre, J et al. (1992) Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. I. Methods. Collaborative Ovarian Cancer Group. Am J Epidemiol 136:1175-83