Abstract

The primary objective of this proposal is to develop a biobehavioral animal model that will allow for better design of experiments investigating TMJ inflammation. The working hypothesis is that animal feeding patterns will change and will be directly correlated with biological markers during complete Freud's adjuvant (CFA) induced TMJ inflammation. Feeding behavior will be determined via a sophisticated and highly sensitive method of computer operated meal pattern analyses (MPA). In the first experiment, a generalized model will be further developed that uses MPA to determine behavioral changes during early (+2 days after CFA) and late (+42 days after CFA) stage TMJ inflammation. Meal patterns will be correlated to changes in inflammatory markers including histology, TMJ calcitonin gene related peptide and interleukin-1b, trigeminal ganglia substance P, and plasma stress hormones corticosterone, b-endorphin and oxytocin. A second experiment will repeat these procedures with and without anti-inflammatory treatment. These experiments are intended to provide the clinician with a non- invasive behavioral marker for TMJ inflammation and stress, and a more objective basis for patient diagnosis, treatment and outcomes assessment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Research Grants (R03)
Project #
1R03DE012657-01A1
Application #
6205417
Study Section
Special Emphasis Panel (ZDE1-WG (43))
Program Officer
Kousvelari, Eleni
Project Start
2000-09-01
Project End
2003-05-31
Budget Start
2000-09-01
Budget End
2003-05-31
Support Year
1
Fiscal Year
2000
Total Cost
$27,451
Indirect Cost

  Institution

Name
Texas A&M University
Department
Other Basic Sciences
Type
Schools of Dentistry
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845

  Publications

Kramer, Phillip R; Guan, Guoqiang; Zhou, Jun et al. (2008) Selective blockade of the rat brain aqueduct with thermogelling hydrogel nanoparticle dispersion. Physiol Behav 93:546-52
Guan, Guoqiang; Kerins, Carolyn C; Bellinger, Larry L et al. (2005) Estrogenic effect on swelling and monocytic receptor expression in an arthritic temporomandibular joint model. J Steroid Biochem Mol Biol 97:241-50
Kerins, C A; Carlson, D S; Hinton, R J et al. (2005) Specificity of meal pattern analysis as an animal model of determining temporomandibular joint inflammation/pain. Int J Oral Maxillofac Surg 34:425-31
Kerins, C A; Carlson, D S; McIntosh, J E et al. (2003) Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects. Pharmacol Biochem Behav 75:181-9