This proposal is to request support for a Keystone meeting entitled ?Jaks, Stats and? Immunity?, which will be held in Steamboat Springs, Colorado from January 5-February? 10, 2007. The meeting will address recent advancements concerning the regulation of? Jak activity, of Stat nuclear translocation, the role of non-tyrosine- phosphorylated Stats? and negative regulation of the pathway. It will also explore the dissection and analysis of? pathways that interact with Jaks and Stats in immune responses. During this meeting,? the link of the Jak Stat pathway to innate immune receptors (e.g. TLR) through type I? IFN synthesis, which suggests important functions of Jak-Stat target genes in the? regulation of innate and adaptive immune response, including the regulation of dendritic? cell development and function will be discussed. Finally, novel findings about Jak-Stat? and cancer will also play an important role. Firm links were established both to cell? transformation and the handling of cancers by the immune system. Further insight needs? to be provided into the cancer-promoting or tumoricidal activities of Stats.
