The purpose of this proposal is to convene an international symposium on leishmaniasis? [Integrated Genomics on the Road to Leishmaniasis Control] in September, 2007 to define? future post-genomic research strategies for the development of vaccines and drugs against? leishmaniasis. Leishmaniasis, a parasitic disease, is endemic in 88 resource-poor countries,? with an estimated 12 million people infected world-wide. Leishmaniasis is second only to? malaria amongst the parasitic protozoa in its impact on socio-economic development, with a? DALY burden of 2.4 million. Increasing overlap with the spread of AIDS has resulting in HIV /? Leishmania co-infections as an increasing threat, particularly in Europe, India and East Africa.? The recent completion of Leishmania genome projects, advances in our ability to study immune? mechanisms in experimental models and in humans, and a greater understanding of the? molecular cell biology of the host-parasite interaction. Attendees will include leading? international figures in experimental and clinical immunology, vaccinology, parasite molecular? cell biology, biochemistry and drug design in addition to representatives from major agencies? (TDR, DNDi (Drugs for Neglected Disease Institute (WHO)), One World Health); participants will? include scientists from disease endemic countries (23%) and young investigators (15%).? ? Overall, the objectives for this meeting are:? 1. To bring together key scientists involved in leishmaniasis research, in a setting conducive to? exploring and developing research priorities over the coming decade? 2. To review the state of the art in Leishmania molecular cell biology, biochemistry, hostpathogen? interactions, host genetics and immune response? 3. To formulate key short and medium term objectives for basic research (experimental and? clinical), with high potential for translation into new avenues for leishmaniasis control.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Conference (R13)
Project #
1R13AI077297-01
Application #
7408287
Study Section
Special Emphasis Panel (ZAI1-MJH-M (S1))
Program Officer
Daniels, Susan A
Project Start
2007-09-01
Project End
2008-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
1
Fiscal Year
2007
Total Cost
$4,000
Indirect Cost
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520