? ? Although reductive experimentation will continue to be the mainstay of biomedical research in ? the near term, the systems biology approach represents the vanguard of science for the future. ? Effective use of a systems-based approach can identify context within a greater hierarchy of ? experimental results and reveal relationships that are hidden to the reductive experimentalist. ? The purpose of this meeting is to attract that scientific vanguard leading the charge to apply ? systems approaches to biological and biomedical problems, and to provide an effective forum ? for broader dissemination of these strategies to the biomedical research community. The final ? day of this conference will consist of """"""""hands on"""""""" workshops to introduce computational and ? related tools to interested investigators. Specifically, the conference aims: ? ? 1. To bring together the leaders in applying systems approaches to basic biomedical ? research with those in clinical and translational research to continue the dialogue and ? mutual learning initiated in the first Summit in 2006. ? 2. To engage these leading scientists and policymakers in a discussion on the value of a ? systems approach to biological and biomedical research and on the most expeditious ? means of implementing the application of the systems approach in medicine. ? 3. To provide an in depth description of the technologies of systems approaches as applied ? to cellular and sub-cellular analyses. ? 4. To provide an in depth initiation of the clinical scientist into the application of systems ? approaches in translational and clinical research. ? 5. To provide hands on exposure and training in the applications of systems approaches in ? basic, clinical and translational research. ? ? Finally, since disease rarely involves a single system, diagnosis and treatment would be ? significantly enhanced by integration of extensive data sets; i.e., by applying an integrated ? systems approach. The final broad purpose of this conference is, therefore, to bring the recent ? advances in systems approaches in basic biological research to a clinical and translational ? research audience and to facilitate the intellectual exchange. ? ? ?