NAVBO Workshops at Vascular Biology 2020 October 25-29, 2020 Gurney?s Newport Resort and Marina, Newport, RI Principal Investigator: William A. Muller, MD, PhD Vascular biology has evolved over the past decade as a major cross-disciplinary field of study that addresses global health threats such as acute complications of coronary atherosclerosis as well as other major human diseases. Today, vascular biology contributes to our understanding of diabetes, metabolic syndrome, chronic kidney disease, vein graft failure, neurodegenerative disorders, stroke, hematological disorders, cancer and immune diseases. More important, advances in vascular biology have facilitated the development of many preventive strategies and new therapies. Despite major advances in our understanding of the roles of vascular cells in physiology and pathology, major aspects of the underlying mechanisms remain poorly understood. Hence, major translational opportunities await exploitation. New areas of science have emerged that allow us to better understand the pathogenesis of cardiovascular diseases and develop new therapies, including the role of non-coding RNAs and remote organ crosstalk in the regulation of vascular function. Furthermore, in addition to traditional hypothesis-driven research, holistic approaches such as global ?-omics? screening and systems biology have laid important foundations that further our understanding of vascular biology. To integrate this new knowledge and translate it into potential therapies, our unique program combines two workshops: Signaling in the Cardiovascular System and Vascular Inflammation. It includes specific translational sessions and a pre-meeting for trainees. New this year is an overarching ?neurovascular theme? featuring scientists studying vascular diseases of the CNS, who generally do not attend these meetings.
Our aim i s to provide a forum for basic and clinical researchers in these complementary areas to interact, and to provide a platform for furthering the education and careers of trainees. The workshops are interdisciplinary, allowing vascular biology researchers from academia, industry, and government to come together to address important issues in vascular pathologies and their clinical outcomes. The program is characterized by the presentation of cutting edge research in areas including the neurovascular niche, vessel morphogenesis and remodeling in the brain, acute and chronic neurovascular inflammation; vascular permeability, plasticity, imaging, metabolism, non- coding RNAs, and systems biology; inflammation in special vascular beds; leukocyte-endothelial cell interactions; imaging of, and resolution of inflammation. Three joint sessions will feature important topics: signaling in vascular inflammation, vascular therapeutics, and the high endothelial venule in chronic inflammation and cancer. We believe these topics are highly relevant to the NHLBI?s mission to further our understanding and develop much-needed new therapies for diseases involving the vasculature. In this application, we request funds to partially support this interdisciplinary and international conference, which will serve to bring together investigators from academia, industry, and government, post-doctoral fellows, and graduate students from diverse fields of study for four days of intense discussion and study.
NAVBO Workshops at Vascular Biology 2020 October 25-29, 2020 Gurney?s Newport Resort and Marina, Newport, RI Principal Investigator: William A. Muller, MD, PhD In the planned workshops, scientists will present their new discoveries in the areas of signaling in the vascular system and vascular inflammation to other colleagues and their trainees, as well as scientists in other disciplines such as neurobiology, whose work may be impacted by these discoveries. They will also openly discuss the impact of these discoveries on our current understanding of vascular development and disease. This interaction will promote the development of novel and improved strategies for the treatment of vascular diseases and disorders in various organs and contexts.
