Genetically obese Drosophila has been developed by selecting for starvation resistance. This project will investigate hormonal mechanisms that cause Drosophila to accumulate excess lipids. Genomic methods will be used to identify the genetic basis for lipid storage.
This study uses genetically obese fruit flies as a model to understand genetic factors contributing to human obesity. The goal is to identify genes and hormonal pathways that cause cells and animals to accumulate fat.
| Rajpurohit, Subhash; Gefen, Eran; Bergland, Alan O et al. (2018) Spatiotemporal dynamics and genome-wide association genome-wide association analysis of desiccation tolerance in Drosophila melanogaster. Mol Ecol 27:3525-3540 |
| Hardy, Christopher M; Burke, Molly K; Everett, Logan J et al. (2018) Genome-Wide Analysis of Starvation-Selected Drosophila melanogaster-A Genetic Model of Obesity. Mol Biol Evol 35:50-65 |
| Hardy, Christopher M; Birse, Ryan T; Wolf, Matthew J et al. (2015) Obesity-associated cardiac dysfunction in starvation-selected Drosophila melanogaster. Am J Physiol Regul Integr Comp Physiol 309:R658-67 |
| Slocumb, Melissa E; Regalado, Josue M; Yoshizawa, Masato et al. (2015) Enhanced Sleep Is an Evolutionarily Adaptive Response to Starvation Stress in Drosophila. PLoS One 10:e0131275 |
| Masek, Pavel; Reynolds, Lauren A; Bollinger, Wesley L et al. (2014) Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster. J Exp Biol 217:3122-32 |
