Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants (R21)
Project #
2R21AI039033-05
Application #
6333187
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Program Officer
Gottlieb, Michael
Project Start
2001-04-01
Project End
2003-03-31
Budget Start
2001-04-01
Budget End
2003-03-31
Support Year
5
Fiscal Year
2001
Total Cost
$287,000
Indirect Cost
Name
University of Alabama Birmingham
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Szempruch, Anthony J; Sykes, Steven E; Kieft, Rudo et al. (2016) Extracellular Vesicles from Trypanosoma brucei Mediate Virulence Factor Transfer and Cause Host Anemia. Cell 164:246-257
Greene, Amy Styer; Hajduk, Stephen L (2016) Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei. J Biol Chem 291:3063-75
Sykes, Steven; Szempruch, Anthony; Hajduk, Stephen (2015) The krebs cycle enzyme ?-ketoglutarate decarboxylase is an essential glycosomal protein in bloodstream African trypanosomes. Eukaryot Cell 14:206-15
Harrington, John M; Nishanova, Tuiumkan; Pena, Savannah Rose et al. (2014) A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein. J Biol Chem 289:24811-20
Capewell, Paul; Clucas, Caroline; DeJesus, Eric et al. (2013) The TgsGP gene is essential for resistance to human serum in Trypanosoma brucei gambiense. PLoS Pathog 9:e1003686
Kieft, Rudo; Stephens, Natalie A; Capewell, Paul et al. (2012) Role of expression site switching in the development of resistance to human Trypanosome Lytic Factor-1 in Trypanosoma brucei brucei. Mol Biochem Parasitol 183:8-14
Bullard, Whitney; Kieft, Rudo; Capewell, Paul et al. (2012) Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors. Virulence 3:72-6
Harrington, John M; Scelsi, Chris; Hartel, Andreas et al. (2012) Novel African trypanocidal agents: membrane rigidifying peptides. PLoS One 7:e44384
Capewell, Paul; Veitch, Nicola J; Turner, C Michael R et al. (2011) Differences between Trypanosoma brucei gambiense groups 1 and 2 in their resistance to killing by trypanolytic factor 1. PLoS Negl Trop Dis 5:e1287
Stephens, Natalie A; Hajduk, Stephen L (2011) Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity. Eukaryot Cell 10:1023-33

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