The objective of this application is to provide radionuclides for collaborative research and as a service to funded research investigators throughout the world. To achieve this objective, three research projects are proposed: 1. In research project 1, the investigator will develop routine techniques for the production of large amounts of important radionuclides of copper, gallium yttrium, technetium, bromine and iodine. 2. In research project 2 the imaging physics of positron emitting nuclides of different energy and decay schemes on the image quality will be evaluated. 3. Research project 3 will develop and evaluate molecular modeling methods capable of determining the potential usefulness of radiopharmaceutical labeled with the radionuclides being developed. The three research projects will support collaborative research projects with twelve investigators involving oncological, cardiovascular and neuroscience applications. The majority of the collaborative research projects will utilize a microPET positron emission tomograph designed specifically for imaging transgenic mice and other rodent models. The resource will support several service projects where radionuclides developed under project 1 will be supplied to funded investigators. Training and dissemination of information will be important parts of the resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects (R24)
Project #
1R24CA086307-01
Application #
2907173
Study Section
Special Emphasis Panel (ZRG1-SSS-8 (53))
Program Officer
Croft, Barbara
Project Start
1999-09-01
Project End
2004-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Washington University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Peng, Fangyu; Xie, Fang; Muzik, Otto (2018) Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using 64CuCl2-PET/CT. Aging Dis 9:109-118
Xie, Fang; Xi, Yin; Pascual, Juan M et al. (2017) Age-dependent changes of cerebral copper metabolism in Atp7b -/- knockout mouse model of Wilson's disease by [64Cu]CuCl2-PET/CT. Metab Brain Dis 32:717-726
Xie, Fang; Cai, Huawei; Peng, Fangyu (2017) 64CuCl2 PET/CT imaging of mouse muscular injury induced by electroporation. Am J Nucl Med Mol Imaging 7:33-39
Dearling, Jason L J; Paterson, Brett M; Akurathi, Vamsidhar et al. (2015) The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjug Chem 26:707-17
Peng, Fangyu; Muzik, Otto; Gatson, Joshua et al. (2015) Assessment of Traumatic Brain Injury by Increased 64Cu Uptake on 64CuCl2 PET/CT. J Nucl Med 56:1252-7
Cai, Huawei; Wu, Jiu-sheng; Muzik, Otto et al. (2014) Reduced 64Cu uptake and tumor growth inhibition by knockdown of human copper transporter 1 in xenograft mouse model of prostate cancer. J Nucl Med 55:622-8
O'Neill, Allison F; Dearling, Jason L J; Wang, Yuchuan et al. (2014) Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res 20:678-87
Yuan, Jianchao; Zhang, Haiyuan; Kaur, Harpreet et al. (2013) Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography. Mol Imaging 12:203-12
Pressly, Eric D; Pierce, Richard A; Connal, Luke A et al. (2013) Nanoparticle PET/CT imaging of natriuretic peptide clearance receptor in prostate cancer. Bioconjug Chem 24:196-204
Liu, Yongjian; Pierce, Richard; Luehmann, Hannah P et al. (2013) PET imaging of chemokine receptors in vascular injury-accelerated atherosclerosis. J Nucl Med 54:1135-41

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