Abstract

The objective of this competitive renewal application is to provide """"""""non-standard positron emitting radionuclides"""""""" for collaborative research and as a service to investigators funded to carry out cancer research. To achieve this goal two research projects are proposed: 1. In research Project 1 we will continue to develop high yield techniques for the production of the radionuclides 60Cu, 61Cu, 64Cu, 66Ga, 86Y, 94mTc, 76Br, 77Br and 124I. 2. The radionuclides developed in research Project 1 have high-energy positrons and in several cases gamma rays that are emitted in coincidence with the positron. The imaging physics of these nuclides will be evaluated and techniques to improve image resolution of these high-energy positron emitters and improve quantification developed. These two research projects will support collaborative projects with investigators interested in oncologic imaging. Several of the collaborative research projects will utilize the microPET imaging facility in the Division of Radiological Sciences at Washington University. The grant will also supply the long-lived radionuclides to NCI-funded investigators who cannot obtain these nuclides from other sources. A training program is proposed and dissemination of information is an important part of this resource.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Resource-Related Research Projects (R24)
Project #
3R24CA086307-10S1
Application #
7933333
Study Section
Special Emphasis Panel (ZCA1-SRRB-C (M3))
Program Officer
Zhang, Huiming
Project Start
1999-09-01
Project End
2011-08-31
Budget Start
2009-09-01
Budget End
2011-08-31
Support Year
10
Fiscal Year
2009
Total Cost
$556,000
Indirect Cost

  Institution

Name
Washington University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Peng, Fangyu; Xie, Fang; Muzik, Otto (2018) Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using 64CuCl2-PET/CT. Aging Dis 9:109-118
Xie, Fang; Xi, Yin; Pascual, Juan M et al. (2017) Age-dependent changes of cerebral copper metabolism in Atp7b -/- knockout mouse model of Wilson's disease by [64Cu]CuCl2-PET/CT. Metab Brain Dis 32:717-726
Xie, Fang; Cai, Huawei; Peng, Fangyu (2017) 64CuCl2 PET/CT imaging of mouse muscular injury induced by electroporation. Am J Nucl Med Mol Imaging 7:33-39
Dearling, Jason L J; Paterson, Brett M; Akurathi, Vamsidhar et al. (2015) The ionic charge of copper-64 complexes conjugated to an engineered antibody affects biodistribution. Bioconjug Chem 26:707-17
Peng, Fangyu; Muzik, Otto; Gatson, Joshua et al. (2015) Assessment of Traumatic Brain Injury by Increased 64Cu Uptake on 64CuCl2 PET/CT. J Nucl Med 56:1252-7
Cai, Huawei; Wu, Jiu-sheng; Muzik, Otto et al. (2014) Reduced 64Cu uptake and tumor growth inhibition by knockdown of human copper transporter 1 in xenograft mouse model of prostate cancer. J Nucl Med 55:622-8
O'Neill, Allison F; Dearling, Jason L J; Wang, Yuchuan et al. (2014) Targeted imaging of Ewing sarcoma in preclinical models using a 64Cu-labeled anti-CD99 antibody. Clin Cancer Res 20:678-87
Fu, Maoyong; Brewer, Sarah; Olafsen, Tove et al. (2013) Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments. Mol Imaging Biol 15:68-78
Yuan, Jianchao; Zhang, Haiyuan; Kaur, Harpreet et al. (2013) Synthesis and characterization of theranostic poly(HPMA)-c(RGDyK)-DOTA-64Cu copolymer targeting tumor angiogenesis: tumor localization visualized by positron emission tomography. Mol Imaging 12:203-12
Pressly, Eric D; Pierce, Richard A; Connal, Luke A et al. (2013) Nanoparticle PET/CT imaging of natriuretic peptide clearance receptor in prostate cancer. Bioconjug Chem 24:196-204

Showing the most recent 10 out of 192 publications