The proposed Old Westbury Neuroscience Research Institute will increase the research potential of the SUNY/College at Old Westbury, the faculty and our minority undergraduate students. The goal for the immediate future will be to provide research support for the faculty so that they may obtain R01-type grants, create an environment for the further development of research at the College and increase minority student representation in graduate programs. Over the longer term, the goal will be to increase the numbers of minority students in careers in mental health and drug abuse treatment and prevention. The College is ideally suited to carry out this mission because it has a high percentage of minority students who choose science as a major and a faculty experienced in research and the training of students in neuroscience research with special interests in molecular and cellular approaches. The proposed MIRDP student curriculum is built on a core mental health-neuroscience concentration that already exists. The MIRDP faculty and students will be involved with modern neurobiological-immune techniques (receptor binding, neuroendocrine/behavior, neurotransmitter/ modulator identification, image analysis), and will work as well on many levels (molecular, cellular and organismic) concerned with the elucidating neuropeptide mechanisms. The program will provide seminars/lectures and workshops related to ADAMHA areas. The students will have an opportunity to earn entrance into the existing ADAMHA-MARC Program as well as our Society for Neuroscience Chapter. Our program stresses meritorious mental health-drug abuse research as an immediate goal or measure of our activity. The career choices of the students will be broadened, and their expertise and awareness of mental health and related areas will increase. This program offers a strong """"""""wet-lab"""""""" foundation to foster mental health and drug abuse interests and build on these areas as career options as well as develop both faculty research and institutional advancement in this area.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Resource-Related Research Projects (R24)
Project #
5R24DA009010-11
Application #
6410237
Study Section
Project Start
2000-12-10
Project End
2001-11-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
11
Fiscal Year
2001
Total Cost
$191,175
Indirect Cost
Name
College at Old Westbury
Department
Type
DUNS #
City
Old Westbury
State
NY
Country
United States
Zip Code
11568
Fricchione, Gregory; Zhu, Wei; Cadet, Patrick et al. (2008) Identification of endogenous morphine and a mu3-like opiate alkaloid receptor in human brain tissue taken from a patient with intractable complex partial epilepsy. Med Sci Monit 14:CS45-49
Stefano, George B; Kream, Richard M; Mantione, Kirk J et al. (2008) Endogenous morphine/nitric oxide-coupled regulation of cellular physiology and gene expression: implications for cancer biology. Semin Cancer Biol 18:199-210
Stefano, George B; Bianchi, Enrica; Guarna, Massimo et al. (2007) Nicotine, alcohol and cocaine coupling to reward processes via endogenous morphine signaling: the dopamine-morphine hypothesis. Med Sci Monit 13:RA91-102
Stefano, George B; Kream, Richard M (2007) Endogenous morphine synthetic pathway preceded and gave rise to catecholamine synthesis in evolution (Review). Int J Mol Med 20:837-41
Cadet, Patrick; Mantione, Kirk J; Zhu, Wei et al. (2007) A functionally coupled mu3-like opiate receptor/nitric oxide regulatory pathway in human multi-lineage progenitor cells. J Immunol 179:5839-44
Cheng, Jeanette; Zhang, Chen; Han, Ji-Sheng et al. (2007) TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues. Med Sci Monit 13:BR163-7
Esch, Tobias; Kim, Jae Won; Stefano, George B (2006) Neurobiological implications of eating healthy. Neuro Endocrinol Lett 27:21-33
Kream, Richard M; Stefano, George B (2006) De novo biosynthesis of morphine in animal cells: an evidence-based model. Med Sci Monit 12:RA207-19
Stefano, George B; Fricchione, Gregory L; Esch, Tobias (2006) Relaxation: molecular and physiological significance. Med Sci Monit 12:HY21-31
Zhu, Wei; Mantione, Kirk J; Casares, Federico M et al. (2006) Cholinergic regulation of endogenous morphine release from lobster nerve cord. Med Sci Monit 12:BR295-301

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