Abstract

Project 1 (Co-Project Leaders: Tom Boyce, Michael Kobor) will demonstrate the feasibility of conductinglarge-scale, population-based gene-environment interaction studies by linking epigenetic data from driedblood spots obtained in the BC Newborn Screening Program, maternal and child health data from the BCLinked Health Database, and socioeconomic and developmental data from the province-wide, school entryscreening program coordinated by HELP. Project 1 will also examine the stability of epigeneticmodifications from the newborn period to primary school entry, generate hypotheses regarding epigeneticexpression of stress-related genes at different levels of SES-related neurodevelopmental vulnerability, andseek further evidence for SES-related functional differences in PFC neural circuitry.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects (R24)
Project #
1R24MH081797-01
Application #
7467618
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (50))
Project Start
Project End
Budget Start
2007-09-27
Budget End
2008-07-31
Support Year
1
Fiscal Year
2007
Total Cost
$298,721
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Boyce, W Thomas (2017) Epigenomic Susceptibility to the Social World: Plausible Paths to a ""Newest Morbidity"". Acad Pediatr 17:600-606
Sakhai, Samuel A; Saxton, Katherine; Francis, Darlene D (2016) The influence of early maternal care on perceptual attentional set shifting and stress reactivity in adult rats. Dev Psychobiol 58:39-51
Boyce, W Thomas (2016) Differential Susceptibility of the Developing Brain to Contextual Adversity and Stress. Neuropsychopharmacology 41:142-62
Beery, Annaliese K; McEwen, Lisa M; MacIsaac, Julia L et al. (2016) Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Horm Behav 77:42-52
Lussier, Alexandre A; Stepien, Katarzyna A; Neumann, Sarah M et al. (2015) Prenatal alcohol exposure alters steady-state and activated gene expression in the adult rat brain. Alcohol Clin Exp Res 39:251-61
Boyce, W Thomas; Kobor, Michael S (2015) Development and the epigenome: the 'synapse' of gene-environment interplay. Dev Sci 18:1-23
Jiang, Ruiwei; Jones, Meaghan J; Chen, Edith et al. (2015) Discordance of DNA methylation variance between two accessible human tissues. Sci Rep 5:8257
Quas, Jodi A; Yim, Ilona S; Oberlander, Tim F et al. (2014) The symphonic structure of childhood stress reactivity: patterns of sympathetic, parasympathetic, and adrenocortical responses to psychological challenge. Dev Psychopathol 26:963-82
Guendelman, Sylvia; Goodman, Julia; Kharrazi, Martin et al. (2014) Work-family balance after childbirth: the association between employer-offered leave characteristics and maternity leave duration. Matern Child Health J 18:200-8
Essex, Marilyn J; Boyce, W Thomas; Hertzman, Clyde et al. (2013) Epigenetic vestiges of early developmental adversity: childhood stress exposure and DNA methylation in adolescence. Child Dev 84:58-75

Showing the most recent 10 out of 27 publications